Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NT5E | P21589 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24964991 | 0.83 | CES2 (0.48) | LMNAKMT2AGAAMAPTPOLB | |
| SCHEMBL24963538 | 0.81 | CCR9 (0.38) | LMNAPOLBCES2CES1 | |
| SCHEMBL24963419 | 0.81 | LMNA (0.36) | LMNAKMT2AMEN1MAPK1MAPT | |
| SCHEMBL24964826 | 0.80 | LMNA (0.37) | LMNAKMT2AMEN1NT5EPOLB | |
| SCHEMBL24963420 | 0.78 | LMNA (0.41) | LMNAMAPK1POLBCES2CES1 | |
| SCHEMBL24964808 | 0.78 | CNR1 (0.37) | LMNAPOLB | |
| SCHEMBL24964824 | 0.77 | LMNA (0.54) | LMNAKMT2AMEN1MAPK1MAPT | |
| SCHEMBL24962589 | 0.75 | PROKR1 (0.39) | LMNAGAAPOLBSMN1; SMN2 | |
| SCHEMBL24962584 | 0.74 | LMNA (0.50) | LMNAMAPK1MAPTPOLBPTGS1 | |
| SCHEMBL24962592 | 0.73 | KMT2A (0.44) | LMNAKMT2AMEN1NT5EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023004280-A1 | SELECTIVE PYRAZOLE LRRK2 INHIBITORS AND METHODS FOR USE THEREOF | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2023-01-26 | — | — | WO | disclosed |