Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.34 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | XIAP | P98170 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24963538 | 0.84 | CCR9 (0.38) | LMNAHPGDPOLBCES2CES1 | |
| SCHEMBL24963385 | 0.78 | LMNA (0.43) | LMNACYP1A2CYP2C19CYP2C9POLB | |
| SCHEMBL24964991 | 0.78 | CES2 (0.48) | LMNACYP1A2CYP2C19CYP2C9POLB | |
| SCHEMBL24964824 | 0.75 | LMNA (0.54) | LMNACYP1A2CYP3A4CYP2C19CYP2C9 | |
| SCHEMBL24962589 | 0.72 | PROKR1 (0.39) | LMNAPOLBPROKR1 | |
| SCHEMBL24964808 | 0.72 | CNR1 (0.37) | LMNAHPGDPOLBPROKR1 | |
| SCHEMBL24962584 | 0.72 | LMNA (0.50) | LMNAHPGDCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL24964826 | 0.71 | LMNA (0.37) | LMNAPOLBNPC1RAB9A | |
| SCHEMBL10959319 | 0.70 | HTT (0.41) | HPGDPOLBMAPK1NPC1RAB9A | |
| SCHEMBL24963419 | 0.67 | LMNA (0.36) | LMNACYP3A4POLBMAPK1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023004280-A1 | SELECTIVE PYRAZOLE LRRK2 INHIBITORS AND METHODS FOR USE THEREOF | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2023-01-26 | — | — | WO | disclosed |