SCHEMBL2498538

SCHEMBL2498538

O=C(O[N+]1(O)C(=O)CCC1=O)c1ccc2c(c1)C(=O)OC21c2ccc(O)cc2Oc2cc(O)ccc21

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ FTO Q9C0B1 10/20 0.55
▸ MAPT P10636 3/20 0.55
▸ MEN1 O00255 2/20 0.55
▸ HTT P42858 2/20 0.55
▸ KMT2A Q03164 2/20 0.55
▸ HPGD P15428 2/20 0.55
▸ CYP2C19 P33261 1/20 0.55
▸ RECQL P46063 1/20 0.55
▸ BLM P54132 1/20 0.55
▸ SMAD3 P84022 1/20 0.55
▸ PRMT1 Q99873 1/20 0.55
▸ ACE2 Q9BYF1 1/20 0.55
▸ TDP1 Q9NUW8 1/20 0.55
▸ KCNH2 Q12809 1/20 0.43
▸ ALDH1A1 P00352 2/20 0.41
▸ LMNA P02545 2/20 0.41
▸ USP2 O75604 1/20 0.41
▸ ALOX12 P18054 2/20 0.40
▸ CYP2C9 P11712 1/20 0.40
▸ ALOX15 P16050 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2716585 0.93 FTO (0.54) FTOMAPTMEN1HTTKMT2A
SCHEMBL19126622 0.82 FTO (0.49) FTOMAPTMEN1HTTKMT2A
SCHEMBL6450383 0.81 ALB (0.49) FTOMAPTMEN1HTTKMT2A
SCHEMBL29995636 0.80 FTO (0.56) FTOMAPTMEN1HTTKMT2A
SCHEMBL164316 0.80 FTO (0.56) FTOMAPTMEN1HTTKMT2A
SCHEMBL29501272 0.80 FTO (0.56) FTOMAPTMEN1HTTKMT2A
SCHEMBL30064563 0.80 FTO (0.56) FTOMAPTMEN1HTTKMT2A
SCHEMBL15326936 0.80 FTO (0.60) FTOMAPTMEN1HTTKMT2A
SCHEMBL23002085 0.79 FTO (0.59) FTOMAPTMEN1HTTKMT2A
SCHEMBL20095 0.79 FTO (0.69) FTOMAPTMEN1HTTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024123836-A1 IMMUNE-ACTIVATING COMPLEXES DYNAMIC CELL THERAPIES, INC. (US) 2024-06-13 — — WO disclosed
CN-112074264-B Extracellular vesicles derived from recombinant microorganisms comprising polynucleotides encoding target proteins and uses thereof 玫帝托克斯股份有限公司 2024-05-07 — — CN disclosed
US-20210169802-A1 EXTRACELLULAR VESICLES DERIVED FROM RECOMBINANT MICROORGANISM INCLUDING POLYNUCLEOTIDE ENCODING TARGET PROTEIN AND USE THEREOF MEDYTOX INC. (KR) 2021-06-10 — — US disclosed
EP-3773423-A1 EXTRACELLULAR VESICLES DERIVED FROM RECOMBINANT MICROORGANISM INCLUDING POLYNUCLEOTIDE ENCODING TARGET PROTEIN AND USE THEREOF Medytox Inc. (KR) 2021-02-17 — — EP disclosed
US-10577639-B2 Rapid bed-side measurement of neutrophil elastase activity in biological fluids UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2020-03-03 — — US disclosed
US-9809843-B1 High throughput measurement of DNA base lesion repair capacity THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) 2017-11-07 — — US disclosed
US-8551764-B2 Devices for the detection of the presence and/or activity of proteases in biological samples UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2013-10-08 — — US disclosed
EP-1970445-B1 METHOD FOR NUCLEIC ACID REPLICATION AND NOVEL ARTIFICIAL BASE PAIRS RIKEN (JP) 2012-09-26 — — EP disclosed
EP-2231867-B1 NOVEL DEVICES FOR THE DETECTION OF THE PRESENCE AND/OR ACTIVITY OF PROTEASES IN BIOLOGICAL SAMPLES UNIV FLORIDA (US) 2012-08-08 — — EP disclosed
US-20120135443-A1 Rapid Bed-Side Measurement of Neutrophil Elastase Activity in Biological Fluids UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED 2012-05-31 — — US disclosed
US-8030478-B2 Method for nucleic acid replication and novel artificial base pairs RIKEN (JP) 2011-10-04 — — US disclosed
WO-2010151878-A2 RAPID BED-SIDE MEASUREMENT OF NEUTROPHIL ELASTASE ACTIVITY IN BIOLOGICAL FLUIDS UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2010-12-29 — — WO disclosed
EP-2231867-A2 NOVEL DEVICES FOR THE DETECTION OF THE PRESENCE AND/OR ACTIVITY OF PROTEASES IN BIOLOGICAL SAMPLES University of Florida Research Foundation, Inc. (US) 2010-09-29 — — EP disclosed
US-20100036111-A1 METHOD FOR REPLICATING NUCLEIC ACIDS AND NOVEL UNNATURAL BASE PAIRS RIKEN (JP) 2010-02-11 — — US disclosed
US-20090258382-A1 Novel devices for the detection of the presence and/or activity of proteases in biological samples UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. 2009-10-15 — — US disclosed
WO-2009082445-A2 NOVEL DEVICES FOR THE DETECTION OF THE PRESENCE AND/OR ACTIVITY OF PROTEASES IN BIOLOGICAL SAMPLES UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2009-07-02 — — WO disclosed
EP-1970445-A1 METHOD FOR NUCLEIC ACID REPLICATION AND NOVEL ARTIFICIAL BASE PAIRS Riken (JP) 2008-09-17 — — EP disclosed
US-20060147985-A1 Methods and compositions for monitoring polymer array synthesis AFFYMETRIX, INC. (US) 2006-07-06 — — US disclosed
US-7026114-B1 Methods and compositions for monitoring polymer array synthesis AFFYMETRIX, INC. (US) 2006-04-11 — — US disclosed
EP-0199042-A1 Procainamide assay, tracers, immunogens and antibodies ABBOTT LABORATORIES (US) 1986-10-29 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100036111-A1 METHOD FOR REPLICATING NUCLEIC ACIDS AND NOVEL UNNATURAL BASE PAIRS POLM, POLL, POLRMT FTO 823/4885MAPT 4831/4885MEN1 4033/4885
US-20060147985-A1 Methods and compositions for monitoring polymer array synthesis PFAS, PNKP, PGLS FTO 2465/4885MAPT 1080/4885MEN1 1955/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback