Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 8/20 | 0.59 |
| ▸ | TRPM8 | Q7Z2W7 | 6/20 | 0.59 |
| ▸ | TRPM2 | O94759 | 2/20 | 0.57 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | APEX1 | P27695 | 2/20 | 0.55 |
| ▸ | RECQL | P46063 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | MASP2 | O00187 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10199005 | 0.89 | TRPM2 (0.61) | TRPA1TRPM8TRPM2LTB4RKMT2A | |
| SCHEMBL14206787 | 0.89 | TRPM2 (0.61) | TRPA1TRPM8TRPM2LTB4RKMT2A | |
| SCHEMBL10199018 | 0.80 | ALDH1A1 (0.76) | TRPA1TRPM8TRPM2LTB4RKMT2A | |
| SCHEMBL10936745 | 0.80 | ALDH1A1 (0.76) | TRPA1TRPM8TRPM2LTB4RKMT2A | |
| SCHEMBL294402 | 0.78 | TRPM2 (0.83) | TRPA1TRPM8TRPM2LTB4RKMT2A | |
| SCHEMBL294403 | 0.78 | TRPM2 (0.83) | TRPA1TRPM8TRPM2LTB4RKMT2A | |
| SCHEMBL20342066 | 0.76 | ALDH1A1 (0.50) | TRPA1TRPM8TRPM2LTB4RKMT2A | |
| SCHEMBL8635718 | 0.76 | TRPA1 (0.78) | TRPA1TRPM8TRPM2LTB4RKMT2A | |
| SCHEMBL8635715 | 0.76 | TRPA1 (0.78) | TRPA1TRPM8TRPM2LTB4RKMT2A | |
| SCHEMBL8844920 | 0.76 | LMNA (0.64) | TRPA1TRPM8TRPM2LTB4RKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230145071-A1 | MASP-2 INHIBITORS AND METHODS OF USE | OMEROS CORPORATION | 2023-05-11 | — | — | US | disclosed |
| US-20230145071-A1 | MASP-2 INHIBITORS AND METHODS OF USE | OMEROS CORPORATION | 2023-05-11 | — | — | US | disclosed |
| US-11584714-B2 | MASP-2 inhibitors and methods of use | OMEROS CORPORATION (US) | 2023-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11584714-B2 | MASP-2 inhibitors and methods of use | MASP2, METAP2, SPINT2 | TRPA1 4838/4885TRPM8 3570/4885TRPM2 2624/4885 |
| US-20230145071-A1 | MASP-2 INHIBITORS AND METHODS OF USE | MASP2, METAP2, SPINT2 | TRPA1 4838/4885TRPM8 3570/4885TRPM2 2624/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.