Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13047598 | 0.70 | ADRB1 (0.50) | ADRB1L3MBTL1ALOX5TDP1MAPT | |
| SCHEMBL10373770 | 0.65 | ADRB1 (0.74) | ADRB1L3MBTL1MAPTALDH1A1KCNH2 | |
| SCHEMBL9715330 | 0.65 | ADRB1 (0.62) | ADRB1L3MBTL1ALOX5MAPTHSD17B10 | |
| SCHEMBL11103700 | 0.65 | ADRB1 (0.74) | ADRB1L3MBTL1MAPTALDH1A1KCNH2 | |
| SCHEMBL15507872 | 0.64 | ADRB1 (0.61) | ADRB1L3MBTL1ALOX5TDP1MAPT | |
| SCHEMBL9855189 | 0.64 | L3MBTL1 (0.53) | ADRB1L3MBTL1ALOX5MAPTHSD17B10 | |
| SCHEMBL21182983 | 0.64 | ADRB1 (0.43) | ADRB1L3MBTL1ALOX5TDP1MAPT | |
| SCHEMBL28639508 | 0.63 | ADRB1 (0.50) | ADRB1L3MBTL1ALOX5TDP1MAPT | |
| SCHEMBL10361074 | 0.63 | CFTR (0.42) | ADRB1L3MBTL1ALOX5TDP1MAPT | |
| SCHEMBL28273980 | 0.62 | ACHE (0.52) | ADRB1L3MBTL1ALOX5TDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3498701-B1 | PRMT5 INHIBITORS AND USES THEREOF | EPIZYME INC (US) | 2023-02-22 | — | — | EP | disclosed |