SCHEMBL250995

SCHEMBL250995

Nc1ncnc2c1ncn2N1O[C@H](CO)[C@@H](O)N1O

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ADORA3 P0DMS8 4/20 0.51
▸ ADORA2A P29274 3/20 0.51
▸ ADORA1 P30542 3/20 0.51
▸ PI4KA P42356 2/20 0.51
▸ PI4K2B Q8TCG2 2/20 0.51
▸ PI4K2A Q9BTU6 2/20 0.51
▸ PI4KB Q9UBF8 2/20 0.51
▸ ADORA2B P29275 2/20 0.51
▸ DPP4 P27487 1/20 0.51
▸ MEN1 O00255 1/20 0.51
▸ SLC28A1 O00337 1/20 0.51
▸ MAP3K7 O43318 1/20 0.51
▸ SLC28A2 O43868 1/20 0.51
▸ GAPDH P04406 1/20 0.51
▸ MAPK1 P28482 1/20 0.51
▸ STAT6 P42226 1/20 0.51
▸ KMT2A Q03164 1/20 0.51
▸ SMN1; SMN2 Q16637 1/20 0.51
▸ DOT1L Q8TEK3 1/20 0.51
▸ SLC29A1 Q99808 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25428843 0.80 AHCY (0.46) ADORA3ADORA2AADORA1PI4KAPI4K2B
SCHEMBL29436002 0.79 ADORA3 (0.55) ADORA3ADORA2AADORA1PI4KAPI4K2B
SCHEMBL1276079 0.76 TK1 (0.46) ADORA3MEN1KMT2ASMN1; SMN2POLB
SCHEMBL8632632 0.76 ADORA3 (0.51) ADORA3ADORA2AADORA1PI4KAPI4K2B
SCHEMBL28836965 0.71 ADORA3 (0.63) ADORA3ADORA2AADORA1PI4KAPI4K2B
SCHEMBL29904279 0.71 ADORA3 (0.63) ADORA3ADORA2AADORA1PI4KAPI4K2B
SCHEMBL580610 0.70 ADORA2A (0.64) ADORA3ADORA2AADORA1PI4KAPI4K2B
SCHEMBL31620053 0.69 ADORA3 (0.49) ADORA3ADORA2AADORA1PI4KAPI4K2B
SCHEMBL28413958 0.68 ADORA2A (0.62) ADORA3ADORA2AADORA1PI4KAPI4K2B
SCHEMBL27003093 0.68 AHCY (0.63) ADORA3ADORA2AADORA1PI4KAPI4K2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 534 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230348903-A1 OLIGONUCLEOTIDES Hudson Institute of Medical Research (AU) 2023-11-02 — — US claimed
CN-115916978-A Oligonucleotides 哈德森医学研究所 2023-04-04 — — CN claimed
US-10344261-B2 Immunomodulatory conjugates ASCEND BIOPHARMACEUTICALS LTD (AU) 2019-07-09 — — US claimed
US-20150030626-A1 IMMUNOMODULATORY CONJUGATES Ascend Biopharamaceuticals Ltd (AU) 2015-01-29 — — US claimed
EP-2776070-A1 IMMUNOMODULATORY CONJUGATES Ascend Biopharmaceuticals Ltd (AU) 2014-09-17 — — EP claimed
WO-2013067597-A1 IMMUNOMODULATORY CONJUGATES ASCEND BIOPHARMACEUTICALS PTY LTD (AU) 2013-05-16 — — WO claimed
US-20260069717-A1 MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF MODERNATX INC (US) 2026-03-12 — — US disclosed
US-12502431-B2 Delivery and formulation of engineered nucleic acids MODERNATX, INC. (US) 2025-12-23 — — US disclosed
US-12467050-B2 Methods and compositions for engineering synthetic bioswitches for remote control of biological activity GEORGIA TECH RESEARCH CORPORATION (US) 2025-11-11 — — US disclosed
US-12448622-B2 Oligonucleotides Hudson Institute of Medical Research (AU) 2025-10-21 — — US disclosed
US-20250302925-A1 CONJUGATED CRISPR-CAS COMPLEXES SYNTHEGO CORPORATION 2025-10-02 — — US disclosed
US-12419957-B2 Delivery and formulation of engineered nucleic acids MODERNATX, INC. (US) 2025-09-23 — — US disclosed
US-12416032-B2 Synthetic self-amplifying MRNA molecules with secretion antigen and immunomodulator SunVax mRNA Therapeutics Inc. (US) 2025-09-16 — — US disclosed
CN-1122667-C Process for preparing N6-substituted deaza-adenosine derivatives AVENTIS PHARM PROD INC (US) 2003-10-01 — — CN disclosed
CN-1383427-A Process for preparing N6-substituted deaza-adenosine derivatives AVENTIS PHARM PROD INC (US) 2002-12-04 — — CN disclosed
CN-1333773-A Process for preparing N6-substituted deaza-adenosine derivatives AVENTIS PHARM PROD INC (US) 2002-01-30 — — CN disclosed
US-5817786-A Single-stranded labelled oligonucleotides of preselected sequences MOLECULAR BIOSYSTEMS, INC. (US) 1998-10-06 — — US disclosed
US-5668266-A Synthesis of single-stranded labelled oligonucleotides of preselected sequence SYNGENE, INC. (US) 1997-09-16 — — US disclosed
US-5541313-A Single-stranded labelled oligonucleotides of preselected sequence MOLECULAR BIOSYSTEMS, INC. (US) 1996-07-30 — — US disclosed
US-4948882-A Single-stranded labelled oligonucleotides, reactive monomers and methods of synthesis SYNGENE, INC. (US) 1990-08-14 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10344261-B2 Immunomodulatory conjugates CLEC4M, TLR3, CD74 ADORA3 2908/4885ADORA2A 1926/4885ADORA1 2962/4885
US-20150030626-A1 IMMUNOMODULATORY CONJUGATES CLEC4M, TLR3, CD74 ADORA3 2908/4885ADORA2A 1926/4885ADORA1 2962/4885
US-12419957-B2 Delivery and formulation of engineered nucleic acids RNMT, HNRNPAB, HNRNPA2B1 ADORA3 2836/4885ADORA2A 1890/4885ADORA1 2700/4885
US-20260069717-A1 MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF RNMT, RNGTT, NSUN2 ADORA3 335/4885ADORA2A 393/4885ADORA1 681/4885
US-20250302925-A1 CONJUGATED CRISPR-CAS COMPLEXES DCLRE1B, MRE11, FEN1 ADORA3 4091/4885ADORA2A 3894/4885ADORA1 4333/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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