Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 2/20 | 0.73 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.73 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.73 |
| ▸ | DRD2 | P14416 | 3/20 | 0.60 |
| ▸ | DRD3 | P35462 | 3/20 | 0.60 |
| ▸ | DRD4 | P21917 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | HTR1A | P08908 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.57 |
| ▸ | HTR7 | P34969 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2315895 | 0.98 | ADRA1D (0.73) | ADRA1DADRA1AADRA1BDRD2DRD3 | |
| Hydrochloric Acid SCHEMBL9987656 | 0.97 | ADRA1D (0.72) | ADRA1DADRA1AADRA1BDRD2DRD3 | |
| SCHEMBL6577731 | 0.93 | ADRA1B (0.76) | ADRA1DADRA1AADRA1BDRD2DRD3 | |
| SCHEMBL6771089 | 0.85 | DRD2 (0.76) | ADRA1DADRA1AADRA1BDRD2DRD3 | |
| SCHEMBL10835924 | 0.85 | DRD2 (0.71) | ADRA1DADRA1AADRA1BDRD2DRD3 | |
| SCHEMBL21802151 | 0.84 | DRD2 (0.70) | ADRA1DADRA1AADRA1BDRD2DRD3 | |
| SCHEMBL2316845 | 0.83 | ADRA1B (0.66) | ADRA1DADRA1AADRA1BALDH1A1HTR1A | |
| SCHEMBL2318212 | 0.83 | ADRA1B (0.66) | ADRA1DADRA1AADRA1BALDH1A1HTR1A | |
| SCHEMBL2316840 | 0.83 | ADRA1B (0.66) | ADRA1DADRA1AADRA1BALDH1A1HTR1A | |
| SCHEMBL13484830 | 0.83 | HTR1A (0.71) | ADRA1DADRA1AADRA1BDRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10421763-B2 | Compositions of protein receptor tyrosine kinase inhibitors | PURDUE PHARMA L.P. (US) | 2019-09-24 | — | — | US | disclosed |
| US-10421763-B2 | Compositions of protein receptor tyrosine kinase inhibitors | PURDUE PHARMA L.P. (US) | 2019-09-24 | — | — | US | disclosed |
| US-20180086777-A1 | COMPOSITIONS OF PROTEIN RECEPTOR TYROSINE KINASE INHIBITORS | PURDUE PHARMA L.P. (US) | 2018-03-29 | — | — | US | disclosed |
| US-20180086777-A1 | COMPOSITIONS OF PROTEIN RECEPTOR TYROSINE KINASE INHIBITORS | PURDUE PHARMA L.P. (US) | 2018-03-29 | — | — | US | disclosed |
| US-9738659-B2 | Compositions of protein receptor tyrosine kinase inhibitors | PURDUE PHARMA L.P. (US) | 2017-08-22 | — | — | US | disclosed |
| US-9738659-B2 | Compositions of protein receptor tyrosine kinase inhibitors | PURDUE PHARMA L.P. (US) | 2017-08-22 | — | — | US | disclosed |
| US-9738659-B2 | Compositions of protein receptor tyrosine kinase inhibitors | PURDUE PHARMA L.P. (US) | 2017-08-22 | — | — | US | disclosed |
| US-20150218188-A1 | COMPOSITIONS OF PROTEIN RECEPTOR TYROSINE KINASE INHIBITORS | VM PHARMA LLC (US) | 2015-08-06 | — | — | US | disclosed |
| US-20150218188-A1 | COMPOSITIONS OF PROTEIN RECEPTOR TYROSINE KINASE INHIBITORS | VM PHARMA LLC (US) | 2015-08-06 | — | — | US | disclosed |
| US-20150218188-A1 | COMPOSITIONS OF PROTEIN RECEPTOR TYROSINE KINASE INHIBITORS | VM PHARMA LLC (US) | 2015-08-06 | — | — | US | disclosed |
| US-8809530-B1 | Compositions of protein receptor tyrosine kinase inhibitors | VM PHARMA LLC (US) | 2014-08-19 | — | — | US | disclosed |
| US-20140228331-A1 | COMPOSITIONS OF PROTEIN RECEPTOR TYROSINE KINASE INHIBITORS | PURDUE PHARMA L.P. | 2014-08-14 | — | — | US | disclosed |
| US-20140228331-A1 | COMPOSITIONS OF PROTEIN RECEPTOR TYROSINE KINASE INHIBITORS | PURDUE PHARMA L.P. | 2014-08-14 | — | — | US | disclosed |
| US-20140228331-A1 | COMPOSITIONS OF PROTEIN RECEPTOR TYROSINE KINASE INHIBITORS | PURDUE PHARMA L.P. | 2014-08-14 | — | — | US | disclosed |
| US-20110301133-A1 | COMPOSITIONS OF PROTEIN RECEPTOR TYROSINE KINASE INHIBITORS | VM PHARMA LLC (US) | 2011-12-08 | — | — | US | disclosed |
| US-20110301133-A1 | COMPOSITIONS OF PROTEIN RECEPTOR TYROSINE KINASE INHIBITORS | VM PHARMA LLC (US) | 2011-12-08 | — | — | US | disclosed |
| US-20110301133-A1 | COMPOSITIONS OF PROTEIN RECEPTOR TYROSINE KINASE INHIBITORS | VM PHARMA LLC (US) | 2011-12-08 | — | — | US | disclosed |
| EP-2376495-A2 | COMPOSITIONS OF PROTEIN RECEPTOR TYROSINE KINASE INHIBITORS | VM Pharma LLC (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010077680-A2 | COMPOSITIONS OF PROTEIN RECEPTOR TYROSINE KINASE INHIBITORS | VM DISCOVERY INC. (US) | 2010-07-08 | — | — | WO | disclosed |
| WO-2010077680-A2 | COMPOSITIONS OF PROTEIN RECEPTOR TYROSINE KINASE INHIBITORS | VM DISCOVERY INC. (US) | 2010-07-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150218188-A1 | COMPOSITIONS OF PROTEIN RECEPTOR TYROSINE KINASE INHIBITORS | NGFR, NGF, GRB2 | ADRA1D 1950/4885ADRA1A 2175/4885ADRA1B 2077/4885 |
| US-10421763-B2 | Compositions of protein receptor tyrosine kinase inhibitors | NGFR, NGF, GRB2 | ADRA1D 1950/4885ADRA1A 2175/4885ADRA1B 2077/4885 |
| US-20140228331-A1 | COMPOSITIONS OF PROTEIN RECEPTOR TYROSINE KINASE INHIBITORS | NGFR, NGF, GRB2 | ADRA1D 1950/4885ADRA1A 2175/4885ADRA1B 2077/4885 |
| US-20180086777-A1 | COMPOSITIONS OF PROTEIN RECEPTOR TYROSINE KINASE INHIBITORS | NGFR, NGF, GRB2 | ADRA1D 2099/4885ADRA1A 2408/4885ADRA1B 2343/4885 |
| US-20110301133-A1 | COMPOSITIONS OF PROTEIN RECEPTOR TYROSINE KINASE INHIBITORS | NGFR, NGF, GRB2 | ADRA1D 1950/4885ADRA1A 2175/4885ADRA1B 2077/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.