Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.76 |
| ▸ | DRD3 | P35462 | 5/20 | 0.76 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.72 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.72 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.72 |
| ▸ | HTR1A | P08908 | 4/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.72 |
| ▸ | HTR7 | P34969 | 2/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.72 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.72 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.71 |
| ▸ | GLA | P06280 | 1/20 | 0.71 |
| ▸ | HPGD | P15428 | 1/20 | 0.71 |
| ▸ | HTR2A | P28223 | 1/20 | 0.60 |
| ▸ | HTR6 | P50406 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10835355 | 0.87 | DRD2 (0.79) | DRD2DRD3ADRA1DADRA1AADRA1B | |
| SCHEMBL10835973 | 0.86 | DRD2 (1.00) | DRD2DRD3ADRA1DADRA1AADRA1B | |
| SCHEMBL2510367 | 0.85 | ADRA1D (0.73) | DRD2DRD3ADRA1DADRA1AADRA1B | |
| Nan-190 SCHEMBL30080779 | 0.84 | HTR1A (1.00) | DRD2DRD3ADRA1DADRA1AADRA1B | |
| Nan-190 SCHEMBL2231820 | 0.84 | HTR1A (1.00) | DRD2DRD3ADRA1DADRA1AADRA1B | |
| Nan-190 SCHEMBL29389115 | 0.84 | HTR1A (1.00) | DRD2DRD3ADRA1DADRA1AADRA1B | |
| SCHEMBL2315895 | 0.83 | ADRA1D (0.73) | DRD2DRD3ADRA1DADRA1AADRA1B | |
| Nan-190 SCHEMBL29390376 | 0.83 | ALDH1A1 (1.00) | DRD2DRD3ADRA1DADRA1AADRA1B | |
| Nan-190 SCHEMBL4083153 | 0.83 | ALDH1A1 (1.00) | DRD2DRD3ADRA1DADRA1AADRA1B | |
| SCHEMBL14761599 | 0.83 | HTR1A (0.98) | DRD2DRD3ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6680319-B2 | TREATMENT OF OBSTRUCTIVE SYNDROMES OF THE LOWER URINARY TRACT, INCLUDING BENIGN PROSTATIC HYPERPLASIA, TREATMENT OF LOWER URINARY TRACT SYMPTOMS | RECORDATI S.A. (CH) | 2004-01-20 | — | — | US | disclosed |
| EP-1226131-B1 | ISOXAZOLECARBOXAMIDE DERIVATIVES | RECORDATI CHEM PHARM (IT) | 2003-12-17 | — | — | EP | disclosed |
| EP-1200445-B1 | THIENOPYRANECARBOXAMIDE DERIVATIVES | RECORDATI CHEM PHARM (IT) | 2003-09-17 | — | — | EP | disclosed |
| EP-1222183-B1 | BENZOPYRAN DERIVATIVES | RECORDATI CHEM PHARM (IT) | 2003-04-23 | — | — | EP | disclosed |
| US-20020193381-A1 | Thienopyranecarboxamide derivatives | RECORDATI S.A. CHEMICAL AND PHARMACEUTICAL COMPANY | 2002-12-19 | — | — | US | disclosed |
| US-20020183290-A1 | Adrenergic receptor antagonists selective for both alpha1A-and alpha1D-subtypes and uses therefor | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY | 2002-12-05 | — | — | US | disclosed |
| US-6486163-B1 | Thienopyranecarboxamide derivatives | RECORDATI S.A. CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 2002-11-26 | — | — | US | disclosed |
| US-20020161012-A1 | Isoxazolecarboxamide derivatives | RECORDATI, S.A., CHEMICAL AND PHARMACEUTICAL COMPANY | 2002-10-31 | — | — | US | disclosed |
| WO-2002060534-A2 | SELECTIVE ALPHA 1 ANTAGONISTS A + D | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA SPA (IT) | 2002-08-08 | — | — | WO | disclosed |
| US-6403594-B1 | UROGENTIAL INFECTIONS, ETC | RECORDATI, S.A. CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 2002-06-11 | — | — | US | disclosed |
| US-6387909-B1 | VISION DEFECTS; BENIGN PROSTATIC HYPERPLASIA | RECORDATI S.A. CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 2002-05-14 | — | — | US | disclosed |
| US-6306861-B1 | ANTISPASMODIC AGENTS AND TREATMENT OF INCONSTANCE | RECORDATI S.A. CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 2001-10-23 | — | — | US | disclosed |
| EP-0625514-B1 | 2-Amino-pyrazin-5-carboxamid derivatives, their preparation and their use in therapy | SYNTHELABO (FR) | 1999-08-25 | — | — | EP | disclosed |
| US-5658587-A | TRANSDERMAL PATCH | FLORA INC. (US) | 1997-08-19 | — | — | US | disclosed |
| US-5420130-A | Adrenergic blocking agents | SYNTHELABO (FR) | 1995-05-30 | — | — | US | disclosed |
| EP-0625514-A1 | 2-Amino-pyrazin-5-carboxamid derivatives, their preparation and their use in therapy | SYNTHELABO (FR) | 1994-11-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020183290-A1 | Adrenergic receptor antagonists selective for both alpha1A-and alpha1D-subtypes and uses therefor | ADRB1, ADRA1D, ADRA1B | DRD2 163/4885DRD3 335/4885ADRA1D 2/4885 |
| US-20020161012-A1 | Isoxazolecarboxamide derivatives | ADRA1D, NMUR1, NMUR2 | DRD2 64/4885DRD3 137/4885ADRA1D 1/4885 |
| US-20020193381-A1 | Thienopyranecarboxamide derivatives | ADRA1D, ADRB3, OPRD1 | DRD2 129/4885DRD3 181/4885ADRA1D 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.