Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | KDM5B | Q9UGL1 | 5/20 | 0.47 |
| ▸ | KDM6B | O15054 | 4/20 | 0.47 |
| ▸ | KDM4A | O75164 | 4/20 | 0.47 |
| ▸ | KDM4D | Q6B0I6 | 4/20 | 0.47 |
| ▸ | HIF1AN | Q9NWT6 | 4/20 | 0.47 |
| ▸ | KDM2A | Q9Y2K7 | 4/20 | 0.47 |
| ▸ | KDM3B | Q7LBC6 | 3/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.44 |
| ▸ | DAO | P14920 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | BRS3 | P32247 | 4/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4428193 | 0.76 | DAO (0.54) | KDM4EKDM5BKDM6BKDM4AKDM4D | |
| SCHEMBL25149517 | 0.76 | LMNA (0.47) | KDM4ENR1H2NR1H3ALDH1A1SMN1; SMN2 | |
| SCHEMBL9754384 | 0.75 | KDM4E (0.59) | KDM4EALDH1A1SMN1; SMN2GAARXFP1 | |
| SCHEMBL7276461 | 0.75 | KDM4E (0.63) | KDM4EKDM5BALDH1A1SMN1; SMN2GAA | |
| SCHEMBL4074628 | 0.72 | KDM4E (1.00) | KDM4EKDM5BKDM4AALDH1A1SMN1; SMN2 | |
| SCHEMBL4430762 | 0.72 | FOLH1 (0.55) | KDM4ENR1H2NR1H3ALDH1A1SMN1; SMN2 | |
| SCHEMBL166927 | 0.71 | FOLH1 (0.66) | KDM4EALDH1A1SMN1; SMN2ADRB2LMNA | |
| SCHEMBL29975597 | 0.71 | FOLH1 (0.66) | KDM4EALDH1A1SMN1; SMN2ADRB2LMNA | |
| Phthalic Acid SCHEMBL4430760 | 0.71 | ALDH1A1 (0.70) | KDM4EDAOALDH1A1SMN1; SMN2ADRB2 | |
| SCHEMBL11536638 | 0.70 | KDM4E (0.56) | KDM4EALDH1A1SMN1; SMN2GAARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023062575-A1 | CYCLIC VINYL SULFONE COMPOUNDS AS WRN INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2023-04-20 | — | — | WO | disclosed |