Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | MC3R | P41968 | 1/20 | 0.40 |
| ▸ | ADA | P00813 | 3/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.32 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.32 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.32 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.32 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.32 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.32 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.32 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.32 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.32 |
| ▸ | PSMA5 | P28066 | 1/20 | 0.32 |
| ▸ | PSMB4 | P28070 | 1/20 | 0.32 |
| ▸ | PSMB6 | P28072 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2519309 | 0.82 | ADORA3 (0.38) | ADORA3TSHRMC4RADRA1AMC3R | |
| SCHEMBL2526538 | 0.79 | P4HTM (0.41) | ADAPSMB11PSMA7PSMB1PSMA1 | |
| Serine SCHEMBL4378456 | 0.75 | SIRT6 (0.48) | SIRT6ADORA3TSHRMC4RADRA1A | |
| Serine SCHEMBL20946271 | 0.75 | SIRT6 (0.48) | SIRT6ADORA3TSHRMC4RADRA1A | |
| Serine SCHEMBL22367625 | 0.75 | SIRT6 (0.48) | SIRT6ADORA3TSHRMC4RADRA1A | |
| SCHEMBL7103591 | 0.72 | SIRT6 (0.31) | SIRT6 | |
| SCHEMBL590665 | 0.72 | SIRT6 (0.42) | SIRT6ADORA3TSHRMC4RADRA1A | |
| SCHEMBL2635320 | 0.71 | SIRT6 (0.73) | SIRT6ADORA3TSHRMC4RADRA1A | |
| SCHEMBL17712841 | 0.69 | SIRT6 (0.64) | SIRT6ADORA3TSHRMC4RADRA1A | |
| Hydrochloric Acid SCHEMBL27917292 | 0.69 | SIRT6 (0.70) | SIRT6ADORA3TSHRMC4RADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376459-B1 | MODIFIED PYRAZINE DERIVATIVES AND USES THEREOF | MEDIBEACON LLC (US) | 2015-02-18 | — | — | EP | disclosed |
| US-20110250139-A1 | Modified Pyrazine Derivatives and Uses Thereof | MEDIBEACON, INC. | 2011-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110250139-A1 | Modified Pyrazine Derivatives and Uses Thereof | GLS, GLS2, PLPBP | SIRT6 2338/4885ADORA3 3339/4885TSHR 1031/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.