SCHEMBL25209286

SCHEMBL25209286

COc1ccn2c(CC(C)N(C)C)cnc2c1

nearest known ligand 0.45

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CSF1R P07333 2/20 0.38
KIT P10721 4/20 0.37
PRMT5 O14744 1/20 0.37
WDR77 Q9BQA1 1/20 0.37
FLT3 P36888 4/20 0.36
GPR139 Q6DWJ6 1/20 0.35
HTR2A P28223 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30429663 1.00 CSF1R (0.38) CSF1RKITPRMT5WDR77FLT3
SCHEMBL25294274 0.84 TAAR1 (0.44) CSF1RKITPRMT5WDR77HTR2A
SCHEMBL25196657 0.84 GPR139 (0.39) CSF1RKITPRMT5WDR77FLT3
SCHEMBL25247711 0.81 CYP11B1 (0.34) PRMT5WDR77FLT3
SCHEMBL30429657 0.79 HTR2A (0.33) HTR2A
SCHEMBL25199418 0.79 HTR2A (0.33) HTR2A
SCHEMBL23114698 0.79 FLT3 (0.42) CSF1RKITPRMT5WDR77FLT3
SCHEMBL25521003 0.78 DNMT1 (0.41) GPR139HTR2A
SCHEMBL25206395 0.78 PRMT5 (0.37) CSF1RKITPRMT5WDR77FLT3
SCHEMBL30429613 0.78 PRMT5 (0.37) CSF1RKITPRMT5WDR77FLT3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260138948-A1 N-SUBSTITUTED INDOLES AS 5-HYDROXYTRYPTAMINE (5-HT) SEROTONIN RECEPTOR AGONISTS AND ANTAGONISTS TERRAN BIOSCIENCES INC (US) 2026-05-21 US disclosed
US-20260078090-A1 N-SUBSTITUTED INDOLES AS 5-HYDROXYTRYPTAMINE (5-HT) SEROTONIN RECEPTOR AGONISTS AND ANTAGONISTS TERRAN BIOSCIENCES INC. 2026-03-19 US disclosed
US-20250059184-A1 IMIDAZOPYRIDINE PSYCHOPLASTOGENS AND USES THEREOF DELIX THERAPEUTICS, INC. 2025-02-20 US disclosed
EP-4423060-A2 PSYCHOPLASTOGENIC N-SUBSTITUTED INDOLES Terran Biosciences, Inc. (US) 2024-09-04 EP disclosed
WO-2023114844-A1 IMIDAZOPYRIDINE PSYCHOPLASTOGENS AND USES THEREOF DELIX THERAPEUTICS, INC. (US) 2023-06-22 WO disclosed
WO-2023114844-A1 IMIDAZOPYRIDINE PSYCHOPLASTOGENS AND USES THEREOF DELIX THERAPEUTICS, INC. (US) 2023-06-22 WO disclosed
US-20230159456-A1 N-SUBSTITUTED INDOLES TERRAN BIOSCIENCES INC (US) 2023-05-25 US disclosed
US-20230159456-A1 N-SUBSTITUTED INDOLES TERRAN BIOSCIENCES INC (US) 2023-05-25 US disclosed
US-20230159456-A1 N-SUBSTITUTED INDOLES TERRAN BIOSCIENCES INC (US) 2023-05-25 US disclosed
WO-2023077127-A2 N-SUBSTITUTED INDOLES TERRAN BIOSCIENCES, INC. (US) 2023-05-04 WO disclosed
WO-2023077127-A2 N-SUBSTITUTED INDOLES TERRAN BIOSCIENCES, INC. (US) 2023-05-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260078090-A1 N-SUBSTITUTED INDOLES AS 5-HYDROXYTRYPTAMINE (5-HT) SEROTONIN RECEPTOR AGONISTS AND ANTAGONISTS HTR1D, TPH1, HTR3D CSF1R 1653/4885KIT 497/4885PRMT5 575/4885
US-20260138948-A1 N-SUBSTITUTED INDOLES AS 5-HYDROXYTRYPTAMINE (5-HT) SEROTONIN RECEPTOR AGONISTS AND ANTAGONISTS HTR1D, HTR2C, TPH1 CSF1R 1402/4885KIT 364/4885PRMT5 946/4885
US-20250059184-A1 IMIDAZOPYRIDINE PSYCHOPLASTOGENS AND USES THEREOF GRIN2A, GAP43, GRIN2C CSF1R 2912/4885KIT 1962/4885PRMT5 1087/4885
US-20230159456-A1 N-SUBSTITUTED INDOLES TPH2, TPH1, AANAT CSF1R 4254/4885KIT 851/4885PRMT5 661/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.