Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Acetyl Tyrosine Ethyl Ester. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 known ✓ | P25103 | 3/20 | 0.56 |
| ▸ | GRIA1 known ✓ | P42261 | 1/20 | 0.48 |
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.47 |
| ▸ | ESR2 known ✓ | Q92731 | 1/20 | 0.47 |
| ▸ | PTGS2 known ✓ | P35354 | 2/20 | 0.45 |
| ▸ | EGFR known ✓ | P00533 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.47 |
| ▸ | MDM4 | O15151 | 1/20 | 0.47 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 1/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.45 |
| ▸ | LY96 | Q9Y6Y9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetyl Tyrosine Ethyl Ester SCHEMBL2521638 | 1.00 | TACR1 (0.56) | TACR1BACE1GRIA1KMT2ANPSR1 | |
| Acetyl Tyrosine Ethyl Ester SCHEMBL14370511 | 0.98 | TACR1 (0.58) | TACR1BACE1GRIA1KMT2ANPSR1 | |
| Acetyl Tyrosine Ethyl Ester SCHEMBL468756 | 0.98 | TACR1 (0.58) | TACR1BACE1GRIA1KMT2ANPSR1 | |
| Acetyl Tyrosine Ethyl Ester SCHEMBL468858 | 0.98 | TACR1 (0.58) | TACR1BACE1GRIA1KMT2ANPSR1 | |
| Acetyl Tyrosine Ethyl Ester SCHEMBL38655891 | 0.97 | TACR1 (0.56) | TACR1BACE1GRIA1KMT2ANPSR1 | |
| SCHEMBL30493599 | 0.93 | TACR1 (0.53) | TACR1BACE1GRIA1KMT2ANPSR1 | |
| SCHEMBL12453492 | 0.88 | TACR1 (0.59) | TACR1CTSSCTSK | |
| SCHEMBL25669503 | 0.88 | TACR1 (0.59) | TACR1CTSSCTSK | |
| SCHEMBL3046854 | 0.87 | TACR1 (0.52) | TACR1GRIA1KMT2ANPSR1TSHR | |
| SCHEMBL3046853 | 0.87 | TACR1 (0.52) | TACR1GRIA1KMT2ANPSR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102219706-B | Preparation method of acetyl tyrosine ethyl ester monohydrate and product thereof | NINGBO ZHENHAI HAIDE BIOCHEM CO LTD | 2013-08-21 | — | — | CN | claimed |
| CN-102219706-A | Preparation method of acetyl tyrosine ethyl ester monohydrate and product thereof | NINGBO ZHENHAI HAIDE BIOCHEM CO LTD | 2011-10-19 | — | — | CN | claimed |
| US-20230168196-A1 | METHOD FOR DETECTING TYROSINE RESIDUE IN SAMPLE, AND TERBIUM COMPOUND TO BE USED FOR SUCH DETECTION | NEC CORPORATION (JP) | 2023-06-01 | — | — | US | disclosed |
| CN-102219706-B | Preparation method of acetyl tyrosine ethyl ester monohydrate and product thereof | NINGBO ZHENHAI HAIDE BIOCHEM CO LTD | 2013-08-21 | — | — | CN | disclosed |
| CN-102219706-B | Preparation method of acetyl tyrosine ethyl ester monohydrate and product thereof | NINGBO ZHENHAI HAIDE BIOCHEM CO LTD | 2013-08-21 | — | — | CN | disclosed |
| CN-102219706-B | Preparation method of acetyl tyrosine ethyl ester monohydrate and product thereof | NINGBO ZHENHAI HAIDE BIOCHEM CO LTD | 2013-08-21 | — | — | CN | disclosed |
| CN-102219706-A | Preparation method of acetyl tyrosine ethyl ester monohydrate and product thereof | NINGBO ZHENHAI HAIDE BIOCHEM CO LTD | 2011-10-19 | — | — | CN | disclosed |
| CN-102219706-A | Preparation method of acetyl tyrosine ethyl ester monohydrate and product thereof | NINGBO ZHENHAI HAIDE BIOCHEM CO LTD | 2011-10-19 | — | — | CN | disclosed |
| CN-102219706-A | Preparation method of acetyl tyrosine ethyl ester monohydrate and product thereof | NINGBO ZHENHAI HAIDE BIOCHEM CO LTD | 2011-10-19 | — | — | CN | disclosed |