SCHEMBL252999

SCHEMBL252999

CCCCCc1cc(N)cc(C(=O)O)n1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 4/20 0.48
HCAR3 P49019 2/20 0.48
NOS2 P35228 1/20 0.41
ECE1 P42892 1/20 0.41
GPR84 Q9NQS5 2/20 0.41
GABRP O00591 2/20 0.40
GABRD O14764 2/20 0.40
GABRA1 P14867 2/20 0.40
GABRB1 P18505 2/20 0.40
GABRG2 P18507 2/20 0.40
GABRB3 P28472 2/20 0.40
GABRA5 P31644 2/20 0.40
GABRA3 P34903 2/20 0.40
GABRA2 P47869 2/20 0.40
GABRB2 P47870 2/20 0.40
GABRA4 P48169 2/20 0.40
GABRE P78334 2/20 0.40
GABRA6 Q16445 2/20 0.40
GABRG1 Q8N1C3 2/20 0.40
GABRG3 Q99928 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19614413 0.78 HCAR2 (0.48) HCAR2HCAR3NOS2ECE1GPR84
SCHEMBL11116628 0.75 RARB (0.49) HCAR2HCAR3PPARAMEN1ALDH1A1
SCHEMBL5488837 0.74 KCNH2 (0.62) HCAR2HCAR3PPARAKDM4ELMNA
SCHEMBL9096019 0.73 KCNH2 (0.66) HCAR2PPARAKDM4EALOX15TSHR
SCHEMBL14028865 0.73 HCAR2 (0.48) HCAR2HCAR3GPR84PPARAKDM4E
SCHEMBL745813 0.73 TSHR (0.61) HCAR2KDM4EMEN1ALDH1A1LMNA
SCHEMBL742374 0.73 TSHR (0.61) HCAR2KDM4EMEN1ALDH1A1LMNA
SCHEMBL2274224 0.72 KCNH2 (0.64) HCAR2PPARAKDM4EALOX15TSHR
SCHEMBL29254156 0.71 TSHR (0.58) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL30938840 0.71 TSHR (0.58) HCAR2KDM4EMEN1ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 150 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230174490-A1 IMPROVED SYNTHESIS OF 6-ARYL-4-AMINOPICOLINATES CORTEVA AGRISCIENCE LLC (US) 2023-06-08 US claimed
EP-4121416-A1 IMPROVED SYNTHESIS OF 6-ARYL-4-AMINOPICOLINATES Corteva Agriscience LLC (US) 2023-01-25 EP claimed
EP-3458442-B1 SYNTHESIS OF 6-ARYL-4-AMINOPICOLINATES AND 2-ARYL-6-AMINOPYRIMIDINE-4-CARBOXYLATES BY DIRECT SUZUKI COUPLING CORTEVA AGRISCIENCE LLC (US) 2022-12-28 EP claimed
CN-115298167-A Improved synthesis of 6-aryl-4-aminopicolinates 科迪华农业科技有限责任公司 2022-11-04 CN claimed
WO-2021188654-A1 IMPROVED SYNTHESIS OF 6-ARYL-4-AMINOPICOLINATES CORTEVA AGRISCIENCE LLC (US) 2021-09-23 WO claimed
US-10544121-B2 Synthesis of 6-aryl-4-aminopicolinates and 2-aryl-6-aminopyrimidine-4-carboxylates by direct suzuki coupling DOW AGROSCIENCES LLC (US) 2020-01-28 US claimed
EP-3458442-A1 SYNTHESIS OF 6-ARYL-4-AMINOPICOLINATES AND 2-ARYL-6-AMINOPYRIMIDINE-4-CARBOXYLATES BY DIRECT SUZUKI COUPLING Dow Agrosciences LLC (US) 2019-03-27 EP claimed
US-20180334444-A1 SYNTHESIS OF 6-ARYL-4-AMINOPICOLINATES AND 2-ARYL-6-AMINOPYRIMIDINE-4-CARBOXYLATES BY DIRECT SUZUKI COUPLING DOW AGROSCIENCES LLC (US) 2018-11-22 US claimed
US-10087164-B2 Synthesis of 6-aryl-4-aminopicolinates and 2-aryl-6-aminopyrimidine-4-carboxylates by direct Suzuki coupling DOW AGROSCIENCES LLC (US) 2018-10-02 US claimed
WO-2017201377-A1 SYNTHESIS OF 6-ARYL-4-AMINOPICOLINATES AND 2-ARYL-6-AMINOPYRIMIDINE-4-CARBOXYLATES BY DIRECT SUZUKI COUPLING DOW AGROSCIENCES LLC (US) 2017-11-23 WO claimed
US-20170334878-A1 SYNTHESIS OF 6-ARYL-4-AMINOPICOLINATES AND 2-ARYL-6-AMINOPYRIMIDINE-4-CARBOXYLATES BY DIRECT SUZUKI COUPLING DOW AGROSCIENCES LLC (US) 2017-11-23 US claimed
EP-2440530-B1 PROCESS FOR THE PREPARATION OF 6-(ARYL)-4-AMINOPICOLINATES DOW AGROSCIENCES LLC (US) 2013-07-24 EP claimed
US-8252938-B2 Process for the preparation of 6-(aryl)-4-aminopicolinates DOW AGROSCIENCES, LLC. (US) 2012-08-28 US claimed
EP-2440530-A1 PROCESS FOR THE PREPARATION OF 6-(ARYL)-4-AMINOPICOLINATES Dow AgroSciences LLC (US) 2012-04-18 EP claimed
WO-2010144380-A1 PROCESS FOR THE PREPARATION OF 6-(ARYL)-4-AMINOPICOLINATES DOW AGROSCIENCES LLC (US) 2010-12-16 WO claimed
US-20100311981-A1 PROCESS FOR THE PREPARATION OF 6-(ARYL)-4-AMINOPICOLINATES DOW AGROSCIENCES LLC (US) 2010-12-09 US claimed
EP-2970185-B1 4-AMINO-6-(HETEROCYCLIC)PICOLINATES AND 6-AMINO-2-(HETEROCYCLIC)PYRIMIDINE-4-CARBOXYLATES AND THEIR USE AS HERBICIDES CORTEVA AGRISCIENCE LLC (US) 2023-07-12 EP disclosed
EP-3440938-B1 4-AMINO-6-(4-SUBSTITUTED-PHENYL)-PICOLINATES AND THEIR USE AS HERBICIDES CORTEVA AGRISCIENCE LLC (US) 2023-07-12 EP disclosed
US-20030114311-A1 6-Aryl-4-aminopicolinates and their use as herbicides CORTEVA AGRISCIENCE LLC 2003-06-19 US disclosed
WO-2003011853-A1 6-ARYL-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2003-02-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180334444-A1 SYNTHESIS OF 6-ARYL-4-AMINOPICOLINATES AND 2-ARYL-6-AMINOPYRIMIDINE-4-CARBOXYLATES BY DIRECT SUZUKI COUPLING DDC, AAAS, AASDHPPT HCAR2 2824/4885HCAR3 3040/4885NOS2 3193/4885
US-20230174490-A1 IMPROVED SYNTHESIS OF 6-ARYL-4-AMINOPICOLINATES AAAS, AADAC, NPEPPS HCAR2 1309/4885HCAR3 551/4885NOS2 4604/4885
US-10087164-B2 Synthesis of 6-aryl-4-aminopicolinates and 2-aryl-6-aminopyrimidine-4-carboxylates by direct Suzuki coupling DDC, AAAS, AASDHPPT HCAR2 2902/4885HCAR3 3079/4885NOS2 3269/4885
US-20170334878-A1 SYNTHESIS OF 6-ARYL-4-AMINOPICOLINATES AND 2-ARYL-6-AMINOPYRIMIDINE-4-CARBOXYLATES BY DIRECT SUZUKI COUPLING DDC, AAAS, AASDHPPT HCAR2 2874/4885HCAR3 2906/4885NOS2 3471/4885
US-20100311981-A1 PROCESS FOR THE PREPARATION OF 6-(ARYL)-4-AMINOPICOLINATES HTR6, CYP46A1, NISCH HCAR2 51/4885HCAR3 14/4885NOS2 4800/4885
US-20030114311-A1 6-Aryl-4-aminopicolinates and their use as herbicides AADAC, DDT, AADAT HCAR2 105/4885HCAR3 10/4885NOS2 4548/4885
US-10544121-B2 Synthesis of 6-aryl-4-aminopicolinates and 2-aryl-6-aminopyrimidine-4-carboxylates by direct suzuki coupling DDC, AAAS, AASDHPPT HCAR2 2824/4885HCAR3 3040/4885NOS2 3193/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.