Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 8/20 | 0.55 |
| ▸ | CHRM3 known ✓ | P20309 | 8/20 | 0.55 |
| ▸ | CHRM2 known ✓ | P08172 | 7/20 | 0.55 |
| ▸ | ACHE known ✓ | P22303 | 3/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 7/20 | 0.55 |
| ▸ | CHRM5 | P08912 | 6/20 | 0.55 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.52 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.52 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.52 |
| ▸ | HTR1A | P08908 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 1/20 | 0.48 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2530101 | 0.98 | CHRM1 (0.53) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Hydrochloric Acid SCHEMBL8135845 | 0.96 | CHRM1 (0.52) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL2530104 | 0.82 | CHRM1 (0.44) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL1683105 | 0.81 | CHRM1 (0.55) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL14742426 | 0.79 | ADRA2A (0.55) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL14742055 | 0.78 | CHRM1 (0.61) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL6033512 | 0.78 | CHRM1 (0.52) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL4594643 | 0.77 | ADRA2A (0.44) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL8218838 | 0.76 | ADRA2A (0.62) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL111370 | 0.76 | PTGS1 (0.44) | CHRM1LMNATSHRSMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110257107-A1 | Compounds for Delivering Amino Acids or Peptides with Antioxidant Activity into Mitochondria | UNIVERSITY OF ROCHESTER (US) | 2011-10-20 | — | — | US | disclosed |
| US-20090298782-A1 | Compounds for Delivering Amino Acids or Peptides with Antioxidant Activity into Mitochondria and Use Thereof | UNIVERSITY OF ROCHESTER (US) | 2009-12-03 | — | — | US | disclosed |
| US-7585846-B2 | Compounds for delivering amino acids or peptides with antioxidant activity into mitochondria and use thereof | UNIVERSITY OF ROCHESTER (US) | 2009-09-08 | — | — | US | disclosed |
| EP-1968650-A2 | COMPOUNDS FOR DELIVERING AMINO ACIDS OR PEPTIDES WITH ANTIOXIDANT ACTIVITY INTO MITOCHONDRIA AND USE THEREOF | University of Rochester (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076323-A2 | COMPOUNDS FOR DELIVERING AMINO ACIDS OR PEPTIDES WITH ANTIOXIDANT ACTIVITY INTO MITOCHONDRIA AND USE THEREOF | UNIVERSITY OF ROCHESTER (US) | 2007-07-05 | — | — | WO | disclosed |
| US-20070099845-A1 | Compounds for delivering amino acids or peptides with antioxidant activity into mitochondria and use thereof | ROCHESTER, UNIVERSITY OF | 2007-05-03 | — | — | US | disclosed |
| EP-1691818-A4 | COMPOUNDS FOR DELIVERING AMINO ACIDS OR PEPTIDES WITH ANTIOXIDANT ACTIVITY INTO MITOCHONDRIA AND USE THEREOF | UNIV ROCHESTER (US) | 2007-01-24 | — | — | EP | disclosed |
| EP-1691818-A2 | COMPOUNDS FOR DELIVERING AMINO ACIDS OR PEPTIDES WITH ANTIOXIDANT ACTIVITY INTO MITOCHONDRIA AND USE THEREOF | University of Rochester (US) | 2006-08-23 | — | — | EP | disclosed |
| US-20060160748-A1 | Compounds for delivering amino acids or peptides with antioxidant activity into mitochondria and use thereof | ROCHESTER, UNIVERSITY OF | 2006-07-20 | — | — | US | disclosed |
| WO-2005051978-A2 | COMPOUNDS FOR DELIVERING AMINO ACIDS OR PEPTIDES WITH ANTIOXIDANT ACTIVITY INTO MITOCHONDRIA AND USE THEREOF | UNIVERSITY OF ROCHESTER (US) | 2005-06-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110257107-A1 | Compounds for Delivering Amino Acids or Peptides with Antioxidant Activity into Mitochondria | TXN2, TXNRD2, AIFM1 | CHRM1 4599/4885CHRM3 4496/4885CHRM2 4700/4885 |
| US-20070099845-A1 | Compounds for delivering amino acids or peptides with antioxidant activity into mitochondria and use thereof | TXN2, GLS, PDF | CHRM1 4809/4885CHRM3 4777/4885CHRM2 4826/4885 |
| US-20060160748-A1 | Compounds for delivering amino acids or peptides with antioxidant activity into mitochondria and use thereof | TXN2, TXNRD2, HSPA9 | CHRM1 4762/4885CHRM3 4674/4885CHRM2 4806/4885 |
| US-20090298782-A1 | Compounds for Delivering Amino Acids or Peptides with Antioxidant Activity into Mitochondria and Use Thereof | TXN2, TXNRD2, HSPA9 | CHRM1 4762/4885CHRM3 4674/4885CHRM2 4806/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.