Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 11/20 | 0.45 |
| ▸ | SMO | Q99835 | 6/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30510766 | 1.00 | TNKS (0.49) | TNKSKMT2APARP1SMOLMNA | |
| SCHEMBL25263299 | 0.86 | TNKS (0.53) | TNKSKMT2APARP1LMNAMAPK1 | |
| SCHEMBL30510758 | 0.85 | KMT2A (0.47) | TNKSKMT2APARP1LMNAMAPK1 | |
| SCHEMBL25310750 | 0.82 | ROCK2 (0.50) | TNKSKMT2APARP1LMNAMAPK1 | |
| SCHEMBL25308938 | 0.82 | TNKS (0.57) | TNKSKMT2APARP1MAPK1 | |
| SCHEMBL25310532 | 0.80 | PARP1 (0.62) | TNKSPARP1 | |
| SCHEMBL30510778 | 0.80 | TNKS (0.49) | TNKSKMT2APARP1 | |
| SCHEMBL25308789 | 0.80 | TNKS (0.51) | TNKSKMT2APARP1SMOLMNA | |
| SCHEMBL25310056 | 0.80 | TNKS (0.49) | TNKSKMT2APARP1 | |
| SCHEMBL25310638 | 0.80 | ROCK2 (0.61) | TNKSKMT2APARP1MAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | disclosed |