Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.52 |
| ▸ | CES1 | P23141 | 1/20 | 0.52 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | NOS1 | P29475 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | OGG1 | O15527 | 1/20 | 0.42 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.41 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1552000 | 0.83 | ESR1 (0.38) | CES2CES1ALDH1A1ALOX15LMNA | |
| SCHEMBL7691823 | 0.81 | CES2 (0.52) | CES2CES1CYP2A6CA1CA2 | |
| SCHEMBL7696634 | 0.81 | CES2 (0.52) | CES2CES1CYP2A6CA1CA2 | |
| SCHEMBL8585167 | 0.79 | CES2 (0.50) | CES2CES1CYP2A6CA1CA2 | |
| SCHEMBL23574687 | 0.77 | CES2 (0.48) | CES2CES1CYP2A6CA1CA2 | |
| SCHEMBL4338484 | 0.77 | CES2 (0.48) | CES2CES1CYP2A6CA1CA2 | |
| SCHEMBL942286 | 0.77 | CES2 (0.48) | CES2CES1CYP2A6CA1CA2 | |
| SCHEMBL17187852 | 0.77 | CES2 (0.62) | CES2CES1CA1CA2NOS1 | |
| SCHEMBL20102 | 0.77 | CES2 (0.62) | CES2CES1CA1CA2NOS1 | |
| SCHEMBL3182088 | 0.77 | ALDH1A1 (0.48) | CES2CES1CYP2A6CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115403483-A | CA-4 derivative containing stilbene or benzophenone skeleton, pharmaceutical composition, preparation method and application thereof | 河南省儿童医院郑州儿童医院 | 2022-11-29 | — | — | CN | claimed |
| CN-115403483-B | CA-4 derivative containing stilbene or diphenyl ketone skeleton, pharmaceutical composition, preparation method and application thereof | 河南省儿童医院郑州儿童医院 | 2024-01-26 | — | — | CN | disclosed |
| CN-115403483-A | CA-4 derivative containing stilbene or benzophenone skeleton, pharmaceutical composition, preparation method and application thereof | 河南省儿童医院郑州儿童医院 | 2022-11-29 | — | — | CN | disclosed |
| US-10451967-B2 | Acid- and radical-generating agent and method for generating acid and radical | FUJIFILM WAKO PURE CHEMICAL CORPORATION (JP) | 2019-10-22 | — | — | US | disclosed |
| US-20160342084-A1 | ACID- AND RADICAL-GENERATING AGENT AND METHOD FOR GENERATING ACID AND RADICAL | FUJIFILM WAKO PURE CHEMICAL CORPORATION (JP) | 2016-11-24 | — | — | US | disclosed |
| CN-104059066-A | Diazacarbazoles And Methods Of Use | GENENTECH INC | 2014-09-24 | — | — | CN | disclosed |
| US-8044075-B2 | IL-8 receptor antagonists | GLAXOSMITHKLINE (US) | 2011-10-25 | — | — | US | disclosed |
| US-20100298387-A1 | IL-8 Receptor Antagonists | SMITHKLINE BEECHAM CORPORATION | 2010-11-25 | — | — | US | disclosed |
| US-7612219-B2 | 11—[ (Z) -3- (dimethylamino) propylidene]—6, 11-dihydro-dibenz [B,E] oxepin-2-YI ]—acetic acid | URQUIMA S.A. (ES) | 2009-11-03 | — | — | US | disclosed |
| EP-2099300-A1 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2009-09-16 | — | — | EP | disclosed |
| US-20090005579-A1 | 11 - [ (Z) -3- (Dimethylamino) Propylidene] - 6, 11-Dihydro-Dibenz [B,E] Oxepin-2-Yl] - Acetic Acid | URQUIMA S.A. (ES) | 2009-01-01 | — | — | US | disclosed |
| WO-2008070707-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-06-12 | — | — | WO | disclosed |
| EP-0635485-B1 | TETRAHYDROPHTHALAMIDE DERIVATIVE, INTERMEDIATE FOR PRODUCING THE SAME, PRODUCTION OF BOTH, AND HERBICIDE CONTAINING THE SAME AS ACTIVE INGREDIENT | SAGAMI CHEM RES (JP) | 1997-06-11 | — | — | EP | disclosed |
| US-5554581-A | Tetrahydrophthalamide derivative, intermediate for producing the same, production of both, and herbicide containing the same as active ingredient | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1996-09-10 | — | — | US | disclosed |
| US-5506190-A | Tetrahydrophthalamide derivative, intermediate for producing the same, production of both, and herbicide containing the same as active ingredient | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1996-04-09 | — | — | US | disclosed |
| EP-0635485-A1 | TETRAHYDROPHTHALAMIDE DERIVATIVE, INTERMEDIATE FOR PRODUCING THE SAME, PRODUCTION OF BOTH, AND HERBICIDE CONTAINING THE SAME AS ACTIVE INGREDIENT | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1995-01-25 | — | — | EP | disclosed |
| EP-0072540-B1 | MELT-ANISOTROPIC WHOLLY AROMATIC POLYESTER, PROCESS FOR PRODUCTION THEREOF, AND FIBERS OR FILMS THEREOF | TEIJIN LIMITED (JP) | 1986-04-23 | — | — | EP | disclosed |
| US-4447593-A | HIGH STRENGTH; MELT-SHAPEABLE; | TEIJIN LIMITED (JP) | 1984-05-08 | — | — | US | disclosed |
| EP-0072540-A2 | Melt-anisotropic wholly aromatic polyester, process for production thereof, and fibers or films thereof | TEIJIN LIMITED (JP) | 1983-02-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090005579-A1 | 11 - [ (Z) -3- (Dimethylamino) Propylidene] - 6, 11-Dihydro-Dibenz [B,E] Oxepin-2-Yl] - Acetic Acid | OPRD1, OPRK1, MAOB | CES2 3482/4885CES1 4189/4885CYP2A6 304/4885 |
| US-10451967-B2 | Acid- and radical-generating agent and method for generating acid and radical | CBR1, HAO2, CBR3 | CES2 1419/4885CES1 1075/4885CYP2A6 375/4885 |
| US-20160342084-A1 | ACID- AND RADICAL-GENERATING AGENT AND METHOD FOR GENERATING ACID AND RADICAL | CBR1, HAO2, CBR3 | CES2 1419/4885CES1 1075/4885CYP2A6 375/4885 |
| US-20100298387-A1 | IL-8 Receptor Antagonists | CXCL8, CCR8, IL1RN | CES2 4007/4885CES1 2435/4885CYP2A6 2823/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.