Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | PAM | P19021 | 2/20 | 0.34 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.33 |
| ▸ | PPARG | P37231 | 6/20 | 0.33 |
| ▸ | PPARD | Q03181 | 6/20 | 0.33 |
| ▸ | PPARA | Q07869 | 6/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.33 |
| ▸ | TSHR | P16473 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TLR2 | O60603 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | FABP4 | P15090 | 2/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.33 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.33 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9517401 | 0.86 | LMNA (0.33) | ALDH1A1MEN1KMT2AHSD17B10FDPS | |
| SCHEMBL6698870 | 0.85 | — | — | |
| SCHEMBL28279514 | 0.82 | NAAA (0.42) | TSHRTDP1MEN1KMT2A | |
| SCHEMBL28006927 | 0.81 | FDPS (0.36) | ALDH1A1MEN1ALOX15KMT2AHSD17B10 | |
| SCHEMBL6929076 | 0.80 | TDP1 (0.36) | AKR1B1PAMGPR84PPARGPPARD | |
| SCHEMBL18140326 | 0.80 | PPARG (0.40) | PPARGPPARDPPARAALDH1A1TDP1 | |
| SCHEMBL7337973 | 0.78 | CES2 (0.35) | AKR1B1PAMGPR84PPARGPPARD | |
| SCHEMBL3683450 | 0.78 | TSHR (0.42) | GPR84PPARGPPARDPPARAHDAC11 | |
| SCHEMBL1456154 | 0.78 | ALDH1A1 (0.38) | AKR1B1TSHRALDH1A1TDP1 | |
| SCHEMBL28115370 | 0.77 | ACLY (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023129564-A9 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2024-02-08 | — | — | WO | disclosed |
| WO-2023129564-A1 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2023-07-06 | — | — | WO | disclosed |
| CN-104470914-A | Synthesis of telaprevir and boceprevir or pharmaceutically acceptable salts or solvates and intermediates thereof including beta-amino acids prepared by Mukaiyama aldol addition | SANDOZ AG | 2015-03-25 | — | — | CN | disclosed |