Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 11/20 | 0.49 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.41 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.40 |
| ▸ | MYC | P01106 | 1/20 | 0.39 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.37 |
| ▸ | OXTR | P30559 | 1/20 | 0.37 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2543774 | 0.85 | NOTUM (0.61) | NOTUMMYCNR4A1LMNA | |
| SCHEMBL2547004 | 0.76 | GPR27 (0.51) | AVPR2LMNA | |
| SCHEMBL1259746 | 0.72 | MYC (0.50) | NOTUMCLCN2MYCNR4A1P2RX7 | |
| SCHEMBL195310 | 0.70 | TSHR (0.63) | CLCN2MYCNR4A1P2RX7KEAP1 | |
| SCHEMBL23382307 | 0.69 | NOTUM (0.72) | NOTUMMYCNR4A1LMNA | |
| SCHEMBL9046825 | 0.69 | LMNA (0.51) | LMNA | |
| SCHEMBL898846 | 0.69 | MARS1 (0.38) | P2RX7 | |
| SCHEMBL786240 | 0.67 | ALDH1A1 (0.63) | CLCN2KEAP1LMNA | |
| SCHEMBL3260482 | 0.66 | NOTUM (1.00) | NOTUMMYCNR4A1 | |
| SCHEMBL1259172 | 0.66 | KDM4E (0.46) | NOX4P2RX7LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8642640-B2 | 1-phenylpyrrole derivatives | EXELIXIS, INC. (US) | 2014-02-04 | — | — | US | disclosed |
| US-20110263544-A1 | 1-Phenylpyrrole Derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2011-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263544-A1 | 1-Phenylpyrrole Derivatives | REN, AGTR1, NR3C2 | NOTUM 1658/4885NOX4 158/4885CLCN2 815/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.