Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN2 | Q96KS0 | 6/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | NSD2 | O96028 | 2/20 | 0.36 |
| ▸ | AR | P10275 | 5/20 | 0.36 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25519495 | 0.83 | EGLN2 (0.46) | EGLN2HSP90AB1NSD2CYP11B1CYP11B2 | |
| SCHEMBL3366225 | 0.77 | HSP90AB1 (0.44) | EGLN2HSP90AB1NSD2CYP11B1CYP11B2 | |
| SCHEMBL25519380 | 0.72 | NLRP3 (0.50) | EGLN2HSP90AB1NSD2CYP11B1CYP11B2 | |
| SCHEMBL3399428 | 0.72 | CYP11B1 (0.39) | EGLN2NSD2TRPV4CYP11B1CYP11B2 | |
| SCHEMBL171819 | 0.71 | KIF11 (0.51) | ARTRPV4KIF11SLC22A12 | |
| SCHEMBL23770666 | 0.71 | KRAS (0.39) | EGLN2NSD2ARTRPV4CYP11B1 | |
| SCHEMBL20116875 | 0.69 | ALDH1A1 (0.45) | EGLN2ARCYP11B1CYP11B2SLC22A12 | |
| SCHEMBL2154193 | 0.69 | CYP11B2 (0.53) | EGLN2ARCYP11B1CYP11B2SLC22A12 | |
| SCHEMBL409405 | 0.68 | TRPV4 (0.53) | ARTRPV4KIF11 | |
| SCHEMBL7604551 | 0.68 | TRPV4 (0.56) | NSD2ARTRPV4KIF11SLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023088987-A1 | PYRIDAZINE DERIVATIVES AS INHIBITORS OF NLRP3 | F. HOFFMANN-LA ROCHE AG (CH) | 2023-05-25 | — | — | WO | disclosed |