Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 9/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | XIAP | P98170 | 3/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | PYGL | P06737 | 1/20 | 0.35 |
| ▸ | PYGM | P11217 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25551278 | 0.81 | HDAC6 (0.44) | RIPK1HTR2AHTR2CHTR2BADORA3 | |
| SCHEMBL25565448 | 0.76 | RIPK1 (0.43) | RIPK1HTR2AHTR2CHTR2BADORA3 | |
| SCHEMBL19496039 | 0.72 | CYP11B1 (0.55) | ADORA3ADORA2A | |
| SCHEMBL19255133 | 0.72 | RIPK1 (0.55) | RIPK1HTR2AHTR2CHTR2BPDPK1 | |
| SCHEMBL19255762 | 0.71 | RIPK1 (0.54) | RIPK1 | |
| SCHEMBL25556119 | 0.70 | CYP11B1 (0.46) | ADORA3ADORA2ACHRNB2CHRNA4 | |
| SCHEMBL25585078 | 0.69 | RIPK1 (0.41) | RIPK1 | |
| SCHEMBL23905992 | 0.69 | PDPK1 (0.58) | PDPK1CHRNB2CHRNA7CHRNA4 | |
| SCHEMBL15222076 | 0.68 | HTR2A (0.46) | HTR2AHTR2CHTR2BCHRNB2CHRNA7 | |
| SCHEMBL21734377 | 0.68 | ALDH1A1 (0.36) | RIPK1PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230159508-A1 | INHIBITORS OF RECEPTOR INTERACTING PROTEIN KINASE I FOR THE TREATMENT OF DISEASE | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2023-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230159508-A1 | INHIBITORS OF RECEPTOR INTERACTING PROTEIN KINASE I FOR THE TREATMENT OF DISEASE | RIPK1, RIPK2, RIPK4 | RIPK1 1/4885HTR2A 3040/4885HTR2C 3753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.