Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KDM1A | O60341 | 3/20 | 0.48 |
| ▸ | MAOA | P21397 | 2/20 | 0.48 |
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | RCOR1 | Q9UKL0 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30772669 | 0.88 | ALDH1A1 (0.50) | LMNASMN1; SMN2HTTKDM1AMAOA | |
| SCHEMBL25568293 | 0.86 | SMN1; SMN2 (0.51) | LMNASMN1; SMN2HTTALDH1A1TSHR | |
| SCHEMBL6535838 | 0.78 | HTT (0.52) | LMNASMN1; SMN2HTTALDH1A1CA12 | |
| Hydrochloric Acid SCHEMBL30117949 | 0.77 | HTT (0.51) | LMNASMN1; SMN2HTTALDH1A1MEN1 | |
| SCHEMBL30603013 | 0.76 | LMNA (0.49) | LMNASMN1; SMN2HTTALDH1A1CA12 | |
| SCHEMBL30603011 | 0.76 | LMNA (0.49) | LMNASMN1; SMN2HTTALDH1A1CA12 | |
| SCHEMBL25568226 | 0.76 | CPB1 (0.46) | LMNASMN1; SMN2HTTKDM1AMAOA | |
| SCHEMBL3947244 | 0.75 | LMNA (0.51) | LMNASMN1; SMN2HTTKDM1AMAOA | |
| SCHEMBL14009946 | 0.75 | LMNA (0.51) | LMNASMN1; SMN2HTTKDM1AMAOA | |
| SCHEMBL3946426 | 0.75 | LMNA (0.51) | LMNASMN1; SMN2HTTKDM1AMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230159517-A1 | CHROMANE AMIDINE MONOBACTAM COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS | MERCK SHARP & DOHME LLC (US) | 2023-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230159517-A1 | CHROMANE AMIDINE MONOBACTAM COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS | TCOF1, SLC10A2, PAM | LMNA 1047/4885SMN1; SMN2 1717/4885HTT 3703/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.