SCHEMBL2562258

SCHEMBL2562258

CCOCCNCC(=O)O

nearest known ligand 0.45

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.41
POLB P06746 1/20 0.41
ALDH1A1 P00352 5/20 0.40
TSHR P16473 2/20 0.40
EGLN1 Q9GZT9 2/20 0.39
THRB P10828 1/20 0.39
SMN1; SMN2 Q16637 2/20 0.37
CYP2D6 P10635 1/20 0.37
EPHX2 P34913 1/20 0.37
TDP1 Q9NUW8 1/20 0.36
LTA4H P09960 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30648987 0.96 ALDH1A1 (0.42) KDM4EPOLBALDH1A1TSHREGLN1
SCHEMBL2607368 0.85 KDM4E (0.40) KDM4EALDH1A1EGLN1SMN1; SMN2CYP2D6
SCHEMBL21806079 0.84 KDM4E (0.50) KDM4EPOLBALDH1A1TSHRTHRB
SCHEMBL22444994 0.82 ALDH1A1 (0.41) KDM4EALDH1A1TSHRTHRBSMN1; SMN2
SCHEMBL7220626 0.80 EPHX2 (0.39) TSHREGLN1THRBEPHX2LTA4H
SCHEMBL7720634 0.80 LTA4H (0.36) TSHREGLN1SMN1; SMN2LTA4H
SCHEMBL25148186 0.79 ALDH1A1 (0.47) KDM4EPOLBALDH1A1TSHRTHRB
SCHEMBL20535410 0.79 ALDH1A1 (0.41) KDM4EALDH1A1TSHREGLN1SMN1; SMN2
SCHEMBL13793645 0.79 KDM4E (0.42) KDM4EPOLBALDH1A1TSHRTHRB
SCHEMBL30547298 0.79 EGLN1 (0.37) KDM4EPOLBALDH1A1EGLN1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118256591-A Cyclic peptide compound having high membrane permeability and library comprising same 中外制药株式会社 2024-06-28 CN disclosed
CN-110869544-B Cyclic peptide compound having high membrane permeability and library comprising same 中外制药株式会社 2024-03-08 CN disclosed
US-11807664-B2 Method for producing cyclic organic compound CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2023-11-07 US disclosed
US-11807664-B2 Method for producing cyclic organic compound CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2023-11-07 US disclosed
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-11225655-B2 Bi-functional complexes and methods for making and using such complexes NUEVOLUTION A/S (DK) 2022-01-18 US disclosed
US-20210147475-A1 METHOD FOR PRODUCING CYCLIC ORGANIC COMPOUND CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2021-05-20 US disclosed
US-20200131669-A1 CYCLIC PEPTIDE COMPOUND HAVING HIGH MEMBRANE PERMEABILITY, AND LIBRARY CONTAINING SAME CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2020-04-30 US disclosed
US-20200131669-A1 CYCLIC PEPTIDE COMPOUND HAVING HIGH MEMBRANE PERMEABILITY, AND LIBRARY CONTAINING SAME CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2020-04-30 US disclosed
EP-3636807-A1 CYCLIC PEPTIDE COMPOUND HAVING HIGH MEMBRANE PERMEABILITY, AND LIBRARY CONTAINING SAME Chugai Seiyaku Kabushiki Kaisha (JP) 2020-04-15 EP disclosed
CN-110869544-A Cyclic peptide compound having high membrane permeability and library containing same 中外制药株式会社 2020-03-06 CN disclosed
US-20200040372-A1 METHOD FOR SYNTHESIZING PEPTIDES IN CELL-FREE TRANSLATION SYSTEM CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2020-02-06 US disclosed
EP-3540059-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2019-09-18 EP disclosed
EP-2558577-B1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION AS (DK) 2018-12-12 EP disclosed
US-20130281324-A1 BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2013-10-24 US disclosed
EP-2558577-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2013-02-20 EP disclosed
US-8273776-B2 Biphenyl oxadiazole derivatives as sphingosine-1-phosphate receptors modulators ALLERGAN, INC (US) 2012-09-25 US disclosed
WO-2011127933-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2011-10-20 WO disclosed
US-20110257232-A1 BIPHENYL OXADIAZOLE DERIVATIVES AS SPHINGOSINE-1-PHOSPHATE RECEPTORS MODULATORS ALLERGAN, INC. (US) 2011-10-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200040372-A1 METHOD FOR SYNTHESIZING PEPTIDES IN CELL-FREE TRANSLATION SYSTEM AARS1, NSUN3, RNGTT KDM4E 3061/4885POLB 902/4885ALDH1A1 4757/4885
US-20200131669-A1 CYCLIC PEPTIDE COMPOUND HAVING HIGH MEMBRANE PERMEABILITY, AND LIBRARY CONTAINING SAME VIP, SLC7A1, TRPV1 KDM4E 4113/4885POLB 4724/4885ALDH1A1 4817/4885
US-20210147475-A1 METHOD FOR PRODUCING CYCLIC ORGANIC COMPOUND SCTR, CTRC, DCXR KDM4E 4119/4885POLB 994/4885ALDH1A1 4749/4885
US-20110257232-A1 BIPHENYL OXADIAZOLE DERIVATIVES AS SPHINGOSINE-1-PHOSPHATE RECEPTORS MODULATORS S1PR3, S1PR1, S1PR2 KDM4E 3392/4885POLB 4160/4885ALDH1A1 2444/4885
US-11807664-B2 Method for producing cyclic organic compound SCTR, CTRC, DCXR KDM4E 4119/4885POLB 994/4885ALDH1A1 4749/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.