SCHEMBL256371

SCHEMBL256371

CN1CCc2cncnc21

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 1/20 0.47
MKNK2 Q9HBH9 1/20 0.42
CYP3A4 P08684 10/20 0.40
CYP2D6 P10635 10/20 0.40
CYP1A2 P05177 9/20 0.40
CYP2C19 P33261 6/20 0.40
MEN1 O00255 4/20 0.40
KMT2A Q03164 4/20 0.40
ALDH1A1 P00352 2/20 0.40
HSD17B10 Q99714 4/20 0.39
TSHR P16473 3/20 0.39
ALOX15 P16050 2/20 0.38
CYP2C9 P11712 1/20 0.38
MAPK1 P28482 1/20 0.38
APP P05067 1/20 0.35
NSD2 O96028 1/20 0.33
PKM P14618 1/20 0.33
RECQL P46063 1/20 0.33
MAOA P21397 2/20 0.32
MAOB P27338 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16998406 0.89 GRM5 (0.39) GRM5MKNK2CYP3A4CYP2D6CYP1A2
SCHEMBL19570894 0.79 MKNK2 (0.37) GRM5MKNK2CYP3A4CYP2D6CYP1A2
SCHEMBL21944713 0.76 MKNK2 (0.37) MKNK2CYP3A4CYP2D6CYP1A2CYP2C19
SCHEMBL11916077 0.73 CYP3A4 (0.38) GRM5CYP3A4CYP2D6CYP1A2CYP2C19
SCHEMBL8497505 0.73 MAOA (0.42) CYP3A4CYP2D6CYP1A2CYP2C19MEN1
SCHEMBL16692778 0.73 CYP3A4 (0.36) MKNK2CYP3A4CYP2D6CYP1A2CYP2C19
SCHEMBL18256099 0.72 CYP3A4 (0.35) CYP3A4CYP2D6CYP1A2CYP2C19MEN1
SCHEMBL7923008 0.71 GRM5 (0.54) GRM5MEN1KMT2AALDH1A1MAPK1
SCHEMBL17813500 0.71 GRM5 (0.40) GRM5APPMAOAMAOBDRD2
SCHEMBL30953981 0.71 CYP11B2 (0.40) MKNK2CYP3A4CYP2D6CYP1A2TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11834455-B2 Carm1 inhibitors and uses thereof Epizyme, Inc. (US) 2023-12-05 US disclosed
US-20230279020-A9 CARM1 INHIBITORS AND USES THEREOF Epizyme, Inc. (US) 2023-09-07 US disclosed
WO-2022263548-A1 3-SUBSTITUTED 1H-PYRROLO[2,3-B]PYRIDINE AS GRK5 MODULATORS LEAD DISCOVERY CENTER GMBH (DE) 2022-12-22 WO disclosed
EP-4104901-A1 3-SUBSTITUTED 1H-PYRROLO[2,3-B]PYRIDINE AS GRK5 MODULATORS Lead Discovery Center GmbH (DE) 2022-12-21 EP disclosed
US-20210155631-A1 CARM1 INHIBITORS AND USES THEREOF EPIZYME INC (US) 2021-05-27 US disclosed
WO-2021038095-A1 PEPTIDES AND METHODS FOR THE CARBON-CARBON BOND FORMATION MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2021-03-04 WO disclosed
EP-3786290-A1 PEPTIDES AND METHODS FOR THE CARBON-CARBON BOND FORMATION Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2021-03-03 EP disclosed
US-10633389-B2 CARM1 inhibitors and uses thereof Epizyme, Inc. (US) 2020-04-28 US disclosed
US-9738651-B2 CARM1 inhibitors and uses thereof Epizyme, Inc. (US) 2017-08-22 US disclosed
WO-2017071636-A1 PHTHALAZINE KETONE DERIVATIVE, AND PREPARATION METHOD AND USE THEREOF 四川科伦博泰生物医药股份有限公司 2017-05-04 WO disclosed
WO-2010128425-A1 GPR 119 MODULATORS PFIZER INC. (US) 2010-11-11 WO disclosed
US-20100285145-A1 GPR 119 MODULATORS PFIZER INC 2010-11-11 US disclosed
EP-2210881-A1 Derivatives of syringolin A Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2010-07-28 EP disclosed
WO-2010081731-A2 DERIVATIVES OF SYRINGOLIN A Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V (DE) 2010-07-22 WO disclosed
US-20100151064-A1 THIAZOLHYDRAZIDES FOR TREATMENT OF NEURODEGENERATIVE DISEASES TECHNISCHE UNIVERSITAT DARMSTADT (DE) 2010-06-17 US disclosed
US-20100151064-A1 THIAZOLHYDRAZIDES FOR TREATMENT OF NEURODEGENERATIVE DISEASES TECHNISCHE UNIVERSITAT DARMSTADT (DE) 2010-06-17 US disclosed
WO-2009068322-A1 SELECTIVE INHIBITION OF POLO-LIKE KINASE 1 MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENS CHAFTEN E.V. (DE) 2009-06-04 WO disclosed
EP-2065039-A1 Selective inhibition of Polo-like kinase 1 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2009-06-03 EP disclosed
WO-2008052804-A1 THIAZOLHYDRAZIDES FOR TREATMENT OF NEURODEGENERATIVE DISEASES MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2008-05-08 WO disclosed
EP-1918286-A1 Thiazolhydrazides for treatment of neurodegenerative diseases MPG Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2008-05-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210155631-A1 CARM1 INHIBITORS AND USES THEREOF CARM1, TIAM1, ADRM1 GRM5 1510/4885MKNK2 3105/4885CYP3A4 1389/4885
US-20230279020-A9 CARM1 INHIBITORS AND USES THEREOF CARM1, TIAM1, ADRM1 GRM5 1510/4885MKNK2 3105/4885CYP3A4 1389/4885
US-11834455-B2 Carm1 inhibitors and uses thereof CARM1, TIAM1, ADRM1 GRM5 1514/4885MKNK2 3066/4885CYP3A4 1387/4885
US-20100285145-A1 GPR 119 MODULATORS GPR119, GPR65, GPR39 GRM5 71/4885MKNK2 2520/4885CYP3A4 2077/4885
US-20100151064-A1 THIAZOLHYDRAZIDES FOR TREATMENT OF NEURODEGENERATIVE DISEASES HTT, MAPT, SNCA GRM5 682/4885MKNK2 1517/4885CYP3A4 2610/4885
US-10633389-B2 CARM1 inhibitors and uses thereof CARM1, TIAM1, ADRM1 GRM5 1510/4885MKNK2 3105/4885CYP3A4 1389/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.