Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11773948 | 0.79 | CTSL (0.60) | HTTPOLBCTSBSMN1; SMN2MAPT | |
| SCHEMBL4146583 | 0.75 | MEN1 (0.69) | HTTPOLBLMNATSHRHPGD | |
| SCHEMBL27540291 | 0.74 | HTT (0.59) | HTTPOLBALDH1A1KDM4EGAA | |
| SCHEMBL12985394 | 0.74 | SMN1; SMN2 (0.50) | HTTPOLBLMNAHPGDSMN1; SMN2 | |
| SCHEMBL12985393 | 0.74 | SMN1; SMN2 (0.50) | HTTPOLBLMNAHPGDSMN1; SMN2 | |
| SCHEMBL10657345 | 0.73 | CTSL (0.50) | HTTPOLBCTSBHPGDALDH1A1 | |
| SCHEMBL10657344 | 0.73 | CTSL (0.50) | HTTPOLBCTSBHPGDALDH1A1 | |
| SCHEMBL24227384 | 0.72 | ALDH1A1 (0.59) | POLBLMNATSHRSMN1; SMN2MEN1 | |
| SCHEMBL10657225 | 0.71 | HTT (0.53) | HTTPOLBLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL31069924 | 0.71 | CA2 (0.67) | HTTCA2TAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023107487-A1 | LONP1 INHIBITOR COMPOUNDS, USES AND METHODS | PRETZEL THERAPEUTICS, INC. (US) | 2023-06-15 | — | — | WO | disclosed |