Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.64 |
| ▸ | RELA | Q04206 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | APP | P05067 | 3/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8184083 | 0.87 | CA2 (0.53) | MAPK1NPC1ALDH1A1TP53MAPT | |
| SCHEMBL3043658 | 0.86 | APP (0.53) | MAPK1NPC1ALDH1A1TP53MAPT | |
| SCHEMBL6286645 | 0.86 | HSP90AA1 (0.53) | MAPK1NPC1ALDH1A1TP53MAPT | |
| SCHEMBL3052870 | 0.83 | APP (0.49) | MAPK1NPC1ALDH1A1TP53MAPT | |
| SCHEMBL6278710 | 0.83 | NPC1 (0.62) | MAPK1NPC1ALDH1A1TP53MAPT | |
| SCHEMBL3051936 | 0.80 | APP (0.52) | MAPK1NPC1ALDH1A1TP53MAPT | |
| SCHEMBL311821 | 0.78 | ALDH1A1 (1.00) | MAPK1NPC1ALDH1A1TP53MAPT | |
| SCHEMBL7768257 | 0.78 | ESR1 (0.56) | KCNH2 | |
| SCHEMBL6173418 | 0.77 | RAB9A (0.68) | MAPK1NPC1ALDH1A1TP53MAPT | |
| SCHEMBL13299933 | 0.75 | APP (0.55) | MAPK1NPC1ALDH1A1TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011132194-A1 | PROCESS FOR THE PREPARATION OF RALOXIFENE HYDROCHLORIDE | HETERO RESEARCH FOUNDATION (IN) | 2011-10-27 | — | — | WO | disclosed |
| EP-0832889-B1 | Process for the synthesis of benzothiophenes | LILLY CO ELI (US) | 2006-03-01 | — | — | EP | disclosed |
| US-6921827-B2 | Process for preparing 3-aryl-benzo{b} thiophenes | ELI LILLY AND COMPANY (US) | 2005-07-26 | — | — | US | disclosed |
| US-20040132775-A1 | Process for preparing 3-aryl-benzo{b} thiophenes | LUKE WAYNE DOUGLAS (US) | 2004-07-08 | — | — | US | disclosed |
| EP-0838464-B1 | Substituted benzo(b)thiophene compounds having activity as selective estrogen receptor modulators | LILLY CO ELI (US) | 2003-09-10 | — | — | EP | disclosed |
| EP-0842930-B1 | Process for the synthesis of benzothiophenes | LILLY CO ELI (US) | 2002-05-15 | — | — | EP | disclosed |
| US-6372945-B1 | OXIDIZING BENZYL SULFIDE, REACTING BENZYL SULFOXIDE FORMED WITH STRONG BASE TO FORM BENZYLIC ANION, CONDENSING ANION WITH BENZALDEHYDE, REACTING CONDENSATION PRODUCT WITH ACID CHLORIDE TO PRODUCE ESTER, TREATING ESTER WITH STRONG BASE | ELI LILLY AND COMPANY | 2002-04-16 | — | — | US | disclosed |
| US-6350777-B2 | METHOXY/ETHOXY SUBSTITUTED 3-AROYL-2-ARYLBENZO(B)THIOPHENES AND BENZO(B)THIOPHENE ANALOGUES; ANTITUMOR AGENTS; CYTOTOXICITY | BAYLOR UNIVERSITY | 2002-02-26 | — | — | US | disclosed |
| US-20010034454-A1 | Description anti-mitotic agents which inhibit tubulin polymerization | BYLOR UNIVERSITY AND ARIZONA DESEASE CONTROL RESEARCH COMMISSION | 2001-10-25 | — | — | US | disclosed |
| EP-0693488-B1 | An improved process for preparing 3-(4-aminoethoxy-benzoyl)benzo beta -thiophenes | LILLY CO ELI (US) | 2001-09-19 | — | — | EP | disclosed |
| US-5606075-A | CYCLIZATION IN THE PRESENCE OF AN ACID CATALYST | ELI LILLY AND COMPANY (US) | 1997-02-25 | — | — | US | disclosed |
| US-5606076-A | CYCLIZATION IN PRESENCE OF AN ACID CATALYST | ELI LILLY AND COMPANY (US) | 1997-02-25 | — | — | US | disclosed |
| WO-1996040677-A1 | PROCESS FOR THE SYNTHESIS OF BENZO[b]THIOPHENES | ELI LILLY AND COMPANY (US) | 1996-12-19 | — | — | WO | disclosed |
| WO-1996040693-A1 | PROCESS FOR THE SYNTHESIS OF VINYL SULFENIC ACID DERIVATIVES | ELI LILLY AND COMPANY (US) | 1996-12-19 | — | — | WO | disclosed |
| WO-1996040676-A1 | PROCESS FOR THE SYNTHESIS OF BENZO[b]THIOPHENES | ELI LILLY AND COMPANY (US) | 1996-12-19 | — | — | WO | disclosed |
| US-5569772-A | CHEMICAL INTERMEDIATES | ELI LILLY AND COMPANY (US) | 1996-10-29 | — | — | US | disclosed |
| US-5523416-A | Process for preparing 3-(4-aminoethoxy-benzoyl) benzo (B)-thiophenes | ELI LILLY AND COMPANY (US) | 1996-06-04 | — | — | US | disclosed |
| US-5514826-A | INTERMEDIATES FOR 2-ARYLBENZO(B)THIOPHENES | ELI LILLY AND COMPANY (US) | 1996-05-07 | — | — | US | disclosed |
| US-5512701-A | REACTING SULFOXIDE DERIVATIVE WITH A SILYATING AGENT TO FORM SULFENATE SILYL ESTER, OPTIONALLY REACTING INTERMEDIATE WITH AN AMINE AND/OR A MERCAPTAN | ELI LILLY AND COMPANY (US) | 1996-04-30 | — | — | US | disclosed |
| EP-0693488-A1 | An improved process for preparing 3-(4-aminoethoxy-benzoyl)benzo beta -thiophenes | ELI LILLY AND COMPANY (US) | 1996-01-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040132775-A1 | Process for preparing 3-aryl-benzo{b} thiophenes | TBCB, CYP1B1, TST | MAPK1 687/4885NPC1 2138/4885ALDH1A1 2025/4885 |
| US-20010034454-A1 | Description anti-mitotic agents which inhibit tubulin polymerization | TUBB, TUBB1, TUBB3 | MAPK1 2104/4885NPC1 3002/4885ALDH1A1 2348/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.