Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IP6K1 | Q92551 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | CHKA | P35790 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16635304 | 0.81 | CHRNB2 (0.38) | ALDH1A1ALOX15HSD17B10SMN1; SMN2 | |
| SCHEMBL16634865 | 0.81 | GSK3A (0.39) | ALDH1A1ALOX15HSD17B10SMN1; SMN2MAPT | |
| SCHEMBL16635338 | 0.81 | FFAR4 (0.44) | ALDH1A1TSHRALOX15HSD17B10SMN1; SMN2 | |
| SCHEMBL29765410 | 0.78 | HTT (0.40) | ALDH1A1MAPK1HTTGAAKDM4E | |
| SCHEMBL16635032 | 0.78 | TRPA1 (0.41) | ALDH1A1KDM4EALOX15HSD17B10MAPT | |
| SCHEMBL18176122 | 0.76 | ALDH1A1 (0.42) | ALDH1A1POLBCHKAHTTGAA | |
| SCHEMBL16879601 | 0.76 | ALDH1A1 (0.47) | ALDH1A1POLBCHKAMAPK1HTT | |
| SCHEMBL27126798 | 0.76 | LMNA (0.48) | HTTKDM4ELMNAHSD17B10 | |
| SCHEMBL25689701 | 0.75 | AR (0.41) | IP6K1ALDH1A1MAPK1HTTGAA | |
| SCHEMBL22909290 | 0.74 | MAPK1 (0.50) | IP6K1ALDH1A1MAPK1HTTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230203019-A1 | Piperazine Cyclic Ureas | SIRONAX (BEIJING) CO., LTD. (CN) | 2023-06-29 | — | — | US | disclosed |
| US-20230192662-A1 | Receptor-Interacting Protein 1 Inhibitors Including Piperazine Heterocyclic Amide Ureas | Sironax Ltd. (KY) | 2023-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230192662-A1 | Receptor-Interacting Protein 1 Inhibitors Including Piperazine Heterocyclic Amide Ureas | RIPK1, RIPK3, RIPK4 | IP6K1 42/4885ALDH1A1 4200/4885POLB 3926/4885 |
| US-20230203019-A1 | Piperazine Cyclic Ureas | RIPK1, RIPK3, RIPK4 | IP6K1 15/4885ALDH1A1 3602/4885POLB 2439/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.