Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | FNTA | P49354 | 2/20 | 0.34 |
| ▸ | PGGT1B | P53609 | 2/20 | 0.34 |
| ▸ | TRPC5 | Q9UL62 | 3/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | TRPC4 | Q9UBN4 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 3/20 | 0.33 |
| ▸ | CA1 | P00915 | 3/20 | 0.33 |
| ▸ | CA2 | P00918 | 3/20 | 0.33 |
| ▸ | CA9 | Q16790 | 3/20 | 0.33 |
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.33 |
| ▸ | FNTB | P49356 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20818376 | 0.77 | ACHE (0.37) | ACHEKMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL20818359 | 0.77 | TRPC5 (0.56) | ALDH1A1TRPC5KCNH2TRPC4 | |
| SCHEMBL20831820 | 0.71 | TRPC5 (0.49) | ALDH1A1MAPTSMN1; SMN2TRPC5P2RX7 | |
| SCHEMBL20831960 | 0.70 | TRPC5 (0.61) | KMT2AALDH1A1SMN1; SMN2TRPC5P2RX7 | |
| SCHEMBL20831621 | 0.69 | RAB9A (0.33) | KMT2AALDH1A1MAPTSMN1; SMN2CA12 | |
| SCHEMBL25706100 | 0.69 | RAB9A (0.39) | KMT2AALDH1A1MAPTSMN1; SMN2CA12 | |
| SCHEMBL25703537 | 0.68 | HSD17B13 (0.38) | ALDH1A1MAPTTRPC5P2RX7TP53 | |
| SCHEMBL25701752 | 0.67 | TRPC5 (0.60) | TRPC5P2RX7KCNH2TRPC4 | |
| SCHEMBL25703193 | 0.66 | TRPC5 (0.51) | ALDH1A1TRPC5P2RX7KCNH2TRPC4 | |
| SCHEMBL20831457 | 0.65 | TRPC5 (0.55) | ALDH1A1MAPTTRPC5KCNH2TRPC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230203028-A1 | PYRIDAZINONES AND METHODS OF USE THEREOF | GFB (ABC), LLC | 2023-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230203028-A1 | PYRIDAZINONES AND METHODS OF USE THEREOF | PDXK, ATP6V1B1, REN | ACHE 403/4885KMT2A 3397/4885DHFR 93/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.