SCHEMBL257286

SCHEMBL257286

N#Cc1cc2nsnc2cc1C#N

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTPN11 Q06124 8/20 0.48
PTPN1 P18031 3/20 0.48
PTPN6 P29350 1/20 0.48
ALDH1A1 P00352 5/20 0.38
MAPT P10636 3/20 0.38
POLB P06746 2/20 0.38
THRB P10828 2/20 0.38
BLM P54132 2/20 0.38
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
NPSR1 Q6W5P4 2/20 0.38
APAF1 O14727 1/20 0.38
NR4A1 P22736 1/20 0.38
RECQL P46063 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
KDM4E B2RXH2 3/20 0.36
HTT P42858 1/20 0.36
RXFP1 Q9HBX9 1/20 0.36
GRM6 O15303 1/20 0.33
GRIA1 P42261 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2728002 0.72 PTPN11 (0.48) PTPN11PTPN1ALDH1A1KDM4ETXNRD1
SCHEMBL14446371 0.71 KDM4E (0.42) PTPN11PTPN1PTPN6ALDH1A1MAPT
SCHEMBL30352788 0.70 ALDH1A1 (0.39) ALDH1A1MAPTPOLBTHRBBLM
SCHEMBL25991821 0.70 ALDH1A1 (0.39) ALDH1A1MAPTPOLBTHRBBLM
SCHEMBL12366184 0.70 ALDH1A1 (0.46) ALDH1A1MAPTPOLBTHRBBLM
SCHEMBL29397592 0.70 ALDH1A1 (0.39) ALDH1A1MAPTPOLBTHRBBLM
SCHEMBL56906 0.69 USP8 (0.40) ALDH1A1MAPTMEN1KMT2ANPSR1
SCHEMBL4261991 0.68 TRPV4 (0.32) MAPTMEN1KMT2AKDM4E
SCHEMBL7061881 0.68 MAPT (0.39) PTPN11ALDH1A1MAPTMEN1KMT2A
SCHEMBL6108284 0.67 ALDH1A1 (0.43) ALDH1A1MAPTPOLBTHRBBLM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3212655-A1 PROCESS FOR PREPARING THIADIAZOLO-ISOINDOLE-DIONE DERIVATIVES Merck Patent GmbH (DE) 2017-09-06 EP claimed
WO-2016066241-A1 PROCESS FOR PREPARING THIADIAZOLO-ISOINDOLE-DIONE DERIVATIVES MERCK PATENT GMBH (DE) 2016-05-06 WO claimed
US-20240061332-A1 METHOD OF PATTERNING SEMICONDUCTOR LAYER Raynergy Tek Incorporation (TW) 2024-02-22 US disclosed
CN-117580423-A Method for patterning semiconductor layer 天光材料科技股份有限公司 2024-02-20 CN disclosed
US-11183637-B2 Organic photodetector Raynergy Tek Incorporation (TW) 2021-11-23 US disclosed
EP-3010992-B1 CONJUGATED POLYMERS RAYNERGY TEK INC (TW) 2021-09-15 EP disclosed
US-20180291036-A1 PROCESS FOR PREPARING THIADIAZOLO-ISOINDOLE-DIONE DERIVATIVES MERCK PATENT GMBH (DE) 2018-10-11 US disclosed
WO-2018119780-A1 WEAK ELECTRON-DONATING BUILDING BLOCKS, COPOLYMERS THEREOF AND RELATED DEVICES SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA (CN) 2018-07-05 WO disclosed
US-9837613-B2 Conjugated polymers MERCK PATENT GMBH (DE) 2017-12-05 US disclosed
US-9837613-B2 Conjugated polymers MERCK PATENT GMBH (DE) 2017-12-05 US disclosed
EP-3212655-A1 PROCESS FOR PREPARING THIADIAZOLO-ISOINDOLE-DIONE DERIVATIVES Merck Patent GmbH (DE) 2017-09-06 EP disclosed
US-9153784-B2 Conjugated polymers MERCK PATENT GMBH (DE) 2015-10-06 US disclosed
US-20150270490-A1 CONJUGATED POLYMERS MERCK PATENT GMBH (DE) 2015-09-24 US disclosed
US-20150270490-A1 CONJUGATED POLYMERS MERCK PATENT GMBH (DE) 2015-09-24 US disclosed
US-20150218115-A1 MATERIALS HAVING ELECTRON DEFICIENT MOIETIES AND METHODS OF SYNTHESIZING THEREOF NATIONAL SCIENCE FOUNDATION 2015-08-06 US disclosed
US-20150218115-A1 MATERIALS HAVING ELECTRON DEFICIENT MOIETIES AND METHODS OF SYNTHESIZING THEREOF NATIONAL SCIENCE FOUNDATION 2015-08-06 US disclosed
EP-2611851-B1 CONJUGATED POLYMERS MERCK PATENT GMBH (DE) 2014-10-29 EP disclosed
US-20130161567-A1 CONJUGATED POLYMERS MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 2013-06-27 US disclosed
US-20130161567-A1 CONJUGATED POLYMERS MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 2013-06-27 US disclosed
WO-2012028246-A1 CONJUGATED POLYMERS MERCK PATENT GMBH (DE) 2012-03-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150270490-A1 CONJUGATED POLYMERS OCIAD2, PARG, PPOX PTPN11 2609/4885PTPN1 3209/4885PTPN6 3034/4885
US-20180291036-A1 PROCESS FOR PREPARING THIADIAZOLO-ISOINDOLE-DIONE DERIVATIVES TDO2, DRD5, DRD4 PTPN11 2813/4885PTPN1 2841/4885PTPN6 3103/4885
US-20130161567-A1 CONJUGATED POLYMERS OCIAD2, PARG, PPOX PTPN11 2609/4885PTPN1 3209/4885PTPN6 3034/4885
US-20150218115-A1 MATERIALS HAVING ELECTRON DEFICIENT MOIETIES AND METHODS OF SYNTHESIZING THEREOF NBAS, EMD, MPO PTPN11 1668/4885PTPN1 2083/4885PTPN6 1413/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.