Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18458781 | 0.79 | TP53 (0.45) | TP53ALOX15 | |
| SCHEMBL18433896 | 0.79 | NOS3 (0.37) | — | |
| SCHEMBL25748028 | 0.78 | PLA2G2A (0.30) | — | |
| SCHEMBL18738841 | 0.76 | CNR1 (0.31) | — | |
| SCHEMBL17164367 | 0.75 | S1PR4 (0.38) | — | |
| SCHEMBL18458344 | 0.75 | TP53 (0.48) | TP53ALOX15 | |
| SCHEMBL16918931 | 0.73 | HTR3E (0.32) | — | |
| SCHEMBL18738859 | 0.72 | CNR1 (0.32) | TP53ALOX15 | |
| SCHEMBL25132526 | 0.72 | TYR (0.32) | — | |
| SCHEMBL17164357 | 0.71 | CHRNB4 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11691986-B2 | PTEFB inhibiting macrocyclic compounds | BAYER AKTIENGESELLSCHAFT (DE) | 2023-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11691986-B2 | PTEFB inhibiting macrocyclic compounds | PCLAF, PPIB, RHEB | TP53 2816/4885ALOX15 1415/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.