Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | SNCA | P37840 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4259494 | 0.83 | MAPT (0.41) | PTGS2SIGMAR1ATMMAPTPGR | |
| SCHEMBL4259499 | 0.83 | MAPT (0.41) | PTGS2SIGMAR1ATMMAPTPGR | |
| SCHEMBL142562 | 0.78 | HSP90AA1 (0.41) | SIGMAR1ATMCYP2C9HRH3EGFR | |
| SCHEMBL28881800 | 0.75 | SIGMAR1 (0.39) | SIGMAR1ATMCYP3A4ALDH1A1ALOX15 | |
| SCHEMBL29258996 | 0.74 | SIGMAR1 (0.45) | SIGMAR1ATMMAPTADORA3CYP2C9 | |
| SCHEMBL6561518 | 0.74 | SIGMAR1 (0.45) | SIGMAR1ATMMAPTADORA3CYP2C9 | |
| SCHEMBL27281924 | 0.74 | SIGMAR1 (0.45) | SIGMAR1ATMCYP2C9LMNACYP1A2 | |
| SCHEMBL5824199 | 0.74 | ALDH1A1 (0.45) | PTGS2CYP2C9CYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL27794644 | 0.72 | SIGMAR1 (0.45) | SIGMAR1ATMADORA3CYP2C9ALDH1A1 | |
| SCHEMBL28461980 | 0.71 | SIGMAR1 (0.50) | SIGMAR1ATMHTR1AADORA3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067622-B2 | Method for producing naringenin derivatives from xanthohumol | HOPSTEINER-HALLERTAUER HOPFENVEREDELUNGSGESELLSCHAFT M.B.H. (DE) | 2011-11-29 | — | — | US | disclosed |
| US-20090227806-A1 | METHOD FOR PRODUCING NARINGENIN DERIVATIVES FROM XANTHOHUMOL | HOPSTEINER-HALLERTAUER HOPFENVEREDELUNGSGESELLSCHAFT M.B.H. (DE) | 2009-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227806-A1 | METHOD FOR PRODUCING NARINGENIN DERIVATIVES FROM XANTHOHUMOL | CYP8B1, DOHH, XDH | PTGS2 459/4885SIGMAR1 2533/4885ATM 2985/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.