Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.49 |
| ▸ | TERT | O14746 | 2/20 | 0.47 |
| ▸ | GAK | O14976 | 2/20 | 0.45 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.45 |
| ▸ | COQ8A | Q8NI60 | 2/20 | 0.45 |
| ▸ | NLK | Q9UBE8 | 2/20 | 0.45 |
| ▸ | AR | P10275 | 3/20 | 0.43 |
| ▸ | CFB | P00751 | 7/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26317691 | 0.81 | PDE5A (0.43) | GAKRIPK2COQ8ANLKAR | |
| SCHEMBL6201487 | 0.79 | CTSK (0.43) | GAKRIPK2COQ8ANLKPDE5A | |
| SCHEMBL9724306 | 0.78 | KDM4E (0.59) | DOT1LTERTPTPN11 | |
| SCHEMBL24010750 | 0.78 | GAK (0.64) | DOT1LGAKRIPK2COQ8ANLK | |
| SCHEMBL4785913 | 0.78 | LMNA (0.62) | TERTAR | |
| SCHEMBL4744648 | 0.78 | PIN1 (0.41) | TERTAR | |
| SCHEMBL5848248 | 0.76 | DOT1L (0.52) | DOT1LTERTPTPN11 | |
| SCHEMBL11039427 | 0.76 | CRHR1 (0.52) | DOT1LTERT | |
| SCHEMBL24003870 | 0.73 | DOT1L (0.50) | DOT1LTERTPTPN11 | |
| SCHEMBL29324282 | 0.73 | DOT1L (0.53) | DOT1LTERTGAKRIPK2COQ8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230219927-A1 | AKT3 MODULATORS | Georgiamune Inc. | 2023-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230219927-A1 | AKT3 MODULATORS | AKT3, AKT2, PIK3CA | DOT1L 4382/4885TERT 3883/4885GAK 493/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.