SCHEMBL258354

SCHEMBL258354

ClCc1ccccc1-c1cccc(-c2ccccc2CCl)c1

nearest known ligand 0.49

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PTGER4 P35408 8/20 0.49
PTGER3 P43115 8/20 0.49
PTGER1 P34995 7/20 0.49
PTGER2 P43116 7/20 0.49
DPP4 P27487 1/20 0.45
ADRA2C P18825 1/20 0.42
PDCD1 Q15116 1/20 0.39
CD274 Q9NZQ7 1/20 0.39
KMT2A Q03164 2/20 0.38
FOLH1 Q04609 2/20 0.37
AURKA O14965 1/20 0.37
AURKB Q96GD4 1/20 0.37
ALDH1A1 P00352 1/20 0.36
TSHR P16473 1/20 0.36
CHRM1 P11229 2/20 0.35
CHRM3 P20309 2/20 0.35
CYP2A6 P11509 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31454259 0.88 DPP4 (0.41) PTGER4PTGER3PTGER1PTGER2DPP4
SCHEMBL1309290 0.88 HTR7 (0.41) PTGER4PTGER3PTGER1PTGER2DPP4
SCHEMBL83911 0.86 DPP4 (0.60) PTGER4PTGER3PTGER1PTGER2DPP4
Water SCHEMBL10404160 0.84 DPP4 (0.58) PTGER4PTGER3PTGER1PTGER2DPP4
SCHEMBL9456872 0.83 DPP4 (0.50) DPP4PDCD1CD274KMT2AFOLH1
Biphenyl SCHEMBL27671885 0.82 DPP4 (0.56) PTGER4PTGER3PTGER1PTGER2DPP4
SCHEMBL4437334 0.82 RXRA (0.41) PTGER4PTGER3PTGER1PTGER2DPP4
SCHEMBL27602820 0.82 RORC (0.50)
SCHEMBL6165241 0.82 ADRA2C (0.68) ADRA2CALDH1A1TSHR
SCHEMBL31179899 0.81 DPP4 (0.48) PTGER4PTGER3PTGER1PTGER2DPP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2514788-B1 Phosphorus-sulfur flame retardant additives and polymer systems containing same DOW GLOBAL TECHNOLOGIES LLC (US) 2017-02-01 EP disclosed
EP-2514788-A1 Phosphorus-sulfur flame retardant additives and polymer systems containing same Dow Global Technologies LLC (US) 2012-10-24 EP disclosed
US-8058332-B2 Phosphorus-sulfur FR additives and polymer systems containing same DOW GLOBAL TECHNOLOGIES LLC (US) 2011-11-15 US disclosed
US-20110034573-A1 PHOSPHORUS-SULFUR FR ADDITIVES AND POLYMER SYSTEMS CONTAINING SAME THE DOW CHEMICAL COMPANY 2011-02-10 US disclosed
EP-2125946-A2 PHOSPHORUS-SULFUR FR ADDITIVES AND POLYMER SYSTEMS CONTAINING SAME Dow Global Technologies Inc. (US) 2009-12-02 EP disclosed
WO-2008088487-A2 PHOSPHORUS-SULFUR FR ADDITIVES AND POLYMER SYSTEMS CONTAINING SAME DOW GLOBAL TECHNOLOGIES, INC. (US) 2008-07-24 WO disclosed
US-20080153950-A1 Phosphorus-sulfur FR additives and polymer systems containing same DCOMCO, INC. 2008-06-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080153950-A1 Phosphorus-sulfur FR additives and polymer systems containing same TST, FRG1, PFAS PTGER4 2430/4885PTGER3 2578/4885PTGER1 2372/4885
US-20110034573-A1 PHOSPHORUS-SULFUR FR ADDITIVES AND POLYMER SYSTEMS CONTAINING SAME TST, FRG1, PFAS PTGER4 2430/4885PTGER3 2578/4885PTGER1 2372/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.