SCHEMBL2584726

SCHEMBL2584726

CC(C)(C)OC(=O)C[C@H](NC(=O)OCc1ccccc1)C(=O)ON1C(=O)CCC1=O

nearest known ligand 0.51

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
KLK7 P49862 1/20 0.51
KLK5 Q9Y337 1/20 0.51
CASP1 P29466 4/20 0.48
SYK P43405 1/20 0.47
CTSK P43235 4/20 0.45
CTSL P07711 5/20 0.44
CTSB P07858 4/20 0.44
CTSS P25774 1/20 0.44
CACNA1B Q00975 3/20 0.43
PPARA Q07869 1/20 0.43
MMP8 P22894 1/20 0.43
CCNE1 P24864 1/20 0.42
CDK2 P24941 1/20 0.42
GSK3B P49841 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17177676 1.00 KLK7 (0.51) KLK7KLK5CASP1SYKCTSK
SCHEMBL29400686 0.92 KLK7 (0.60) KLK7KLK5CASP1SYKCTSK
SCHEMBL2777934 0.90 SYK (0.46) KLK7KLK5CASP1SYKCTSK
SCHEMBL29401961 0.89 CASP1 (0.51) KLK7KLK5CASP1CTSKCTSL
SCHEMBL8059266 0.88 KLK7 (0.55) KLK7KLK5CASP1SYKCTSK
SCHEMBL3873338 0.88 KLK7 (0.55) KLK7KLK5CASP1SYKCTSK
SCHEMBL22657970 0.86 CASP1 (0.60) CASP1
SCHEMBL22657972 0.86 CASP1 (0.60) CASP1
SCHEMBL45092 0.86 CTSK (0.47) CASP1CTSKCTSLCTSBCTSS
SCHEMBL7327877 0.85 CTSK (0.54) CASP1SYKCTSKCTSLCTSB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4425181-A1 COMPOSITION FOR DETECTING OR MEASURING ANALYTE Bertis Inc (KR) 2024-09-04 EP disclosed
US-20240115553-A1 COMPOSITIONS AND METHODS FOR TREATING BRAIN INJURY AZEVAN PHARMACEUTICALS, INC. (US) 2024-04-11 US disclosed
US-20240011979-A1 COMPOSITION FOR DETECTING OR MEASURING ANALYTES BERTIS INC. (KR) 2024-01-11 US disclosed
CN-116829949-A Compositions for detecting or measuring analytes 伯蒂斯有限公司 2023-09-29 CN disclosed
WO-2023075435-A1 COMPOSITION FOR DETECTING OR MEASURING ANALYTE 주식회사 베르티스 2023-05-04 WO disclosed
US-20230123729-A1 COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASES AZEVAN PHARMACEUTICALS INC (US) 2023-04-20 US disclosed
US-11628160-B2 Compositions and methods for treating brain injury AZEVAN PHARMACEUTICALS, INC. (US) 2023-04-18 US disclosed
US-20220409734-A1 ANTIBODY DRUG CONJUGATES TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2022-12-29 US disclosed
US-20220283131-A1 COMPOSITION FOR DETECTING OR MEASURING ANALYTES BERTIS CO., LTD. (KR) 2022-09-08 US disclosed
US-11319306-B2 Compositions and methods for treating neurodegenerative diseases AZEVAN PHARMACEUTICALS, INC. (US) 2022-05-03 US disclosed
US-20090170825-A1 BETA-LACTAMYLALKANOIC ACIDS FOR TREATING PREMENSTRUAL DISORDERS AZEVAN PHARMACEUTICALS, INC. 2009-07-02 US disclosed
US-20080280870-A1 Beta-Lactamyl Phenylalanine, Cysteine, and Serine Vasopressin Antagonists AZEVAN PHARMACEUTICALS, INC. 2008-11-13 US disclosed
WO-2008034032-A2 BETA-LACTAM CANNABINOID RECEPTOR MODULATORS AZEVAN PHARMACEUTICALS, INC. (US) 2008-03-20 WO disclosed
US-7268125-B2 β-lactamyl vasopressin V1a antagonists AZEVAN PHARMACEUTICALS, INC. (US) 2007-09-11 US disclosed
US-20060281728-A1 3-Substituted beta-lactamyl vasopressin v1a antagonists AZEVAN PHARMACEUTICALS, INC. 2006-12-14 US disclosed
US-7119083-B2 β-Lactamyl vasopressin V1a Antagonists AZEVAN PHARMACEUTICALS, INC. (US) 2006-10-10 US disclosed
WO-2005035492-A1 3-SUBSTITUTED β-LACTAMYL VASOPRESSIN V1A ANTAGONISTS SERENIX PHARMACEUTICALS, LLC. (US) 2005-04-21 WO disclosed
US-20040266750-A1 Beta-lactamyl vasopressin v1aantagonists AZEVAN PHARMACEUTICALS, INC. 2004-12-30 US disclosed
EP-1434763-A2 BETA-LACTAMYL VASOPRESSIN V1A ANTAGONISTS Serenix Pharmaceuticals, LLC (US) 2004-07-07 EP disclosed
WO-2003031407-A2 β-LACTAMYL VASOPRESSIN VlaANTAGONISTS SERENIX PHARMACEUTICALS, LLC (US) 2003-04-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240115553-A1 COMPOSITIONS AND METHODS FOR TREATING BRAIN INJURY FABP7, PYGB, CHAT KLK7 798/4885KLK5 402/4885CASP1 667/4885
US-20080280870-A1 Beta-Lactamyl Phenylalanine, Cysteine, and Serine Vasopressin Antagonists AVPR2, AVPR1A, AVPR1B KLK7 1308/4885KLK5 728/4885CASP1 1836/4885
US-20060281728-A1 3-Substituted beta-lactamyl vasopressin v1a antagonists AVPR1A, AVPR2, AVPR1B KLK7 733/4885KLK5 466/4885CASP1 2310/4885
US-20090170825-A1 BETA-LACTAMYLALKANOIC ACIDS FOR TREATING PREMENSTRUAL DISORDERS GABBR1, GABBR2, ALAD KLK7 2818/4885KLK5 2631/4885CASP1 3329/4885
US-11319306-B2 Compositions and methods for treating neurodegenerative diseases HTT, AVPR2, AVPR1B KLK7 2207/4885KLK5 813/4885CASP1 3550/4885
US-20220409734-A1 ANTIBODY DRUG CONJUGATES STING1, CGAS, TBK1 KLK7 2352/4885KLK5 2841/4885CASP1 1603/4885
US-20230123729-A1 COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASES HTT, AVPR2, AVPR1B KLK7 2207/4885KLK5 813/4885CASP1 3550/4885
US-11628160-B2 Compositions and methods for treating brain injury FABP7, PYGB, CHAT KLK7 798/4885KLK5 402/4885CASP1 667/4885
US-20040266750-A1 Beta-lactamyl vasopressin v1aantagonists AVPR1A, AVPR2, AVPR1B KLK7 1287/4885KLK5 1040/4885CASP1 1367/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.