SCHEMBL25857355

SCHEMBL25857355

C#Cc1ccc(-c2nnc(N)c3cnccc23)c(OCOCC)c1

nearest known ligand 0.30

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
PIP4K2A P48426 1/20 0.30
IDO1 P14902 1/20 0.30
TDO2 P48775 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25860910 0.87 NCF1 (0.33)
SCHEMBL25854611 0.78 EP300 (0.37) IDO1TDO2
SCHEMBL31314299 0.77 GABRG2 (0.31)
SCHEMBL25858470 0.76 GABRA1 (0.30)
SCHEMBL31496024 0.76 CACNA2D1 (0.31)
SCHEMBL25859255 0.76 CYP1A1 (0.33)
SCHEMBL25296220 0.76 NLRP3 (0.43)
SCHEMBL30488565 0.76 NLRP3 (0.43)
SCHEMBL25296221 0.76 NLRP3 (0.43)
SCHEMBL31314251 0.75 CACNA2D1 (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023131277-A1 NLRP3 INFLAMMASOME INHIBITOR AND USES THEREOF 药捷安康(南京)科技股份有限公司 2023-07-13 WO disclosed