SCHEMBL2586783

SCHEMBL2586783

Cl[Si](c1ccccc1)(c1ccccc1)c1ccccc1Br

nearest known ligand 0.34

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.34
MAPK1 P28482 1/20 0.34
TDP1 Q9NUW8 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30030347 1.00 ALDH1A1 (0.34) ALDH1A1MAPK1TDP1
SCHEMBL9291948 0.83 TSHR (0.33) ALDH1A1TDP1
SCHEMBL7650488 0.76 ALDH1A1 (0.37) ALDH1A1MAPK1TDP1
SCHEMBL28362548 0.76 ALDH1A1 (0.37) ALDH1A1MAPK1TDP1
SCHEMBL2102966 0.75 ALDH1A1 (0.38) ALDH1A1MAPK1TDP1
SCHEMBL9932121 0.74 TSHR (0.41) ALDH1A1
SCHEMBL6931675 0.74 ALDH1A1 (0.36) ALDH1A1MAPK1TDP1
SCHEMBL197123 0.74 TSHR (0.39) ALDH1A1MAPK1TDP1
SCHEMBL1315674 0.73 ACHE (0.39) ALDH1A1TDP1
SCHEMBL15858820 0.73 ESR1 (0.45) ALDH1A1MAPK1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240147840-A1 SPIROFLUORENE SILICON COMPOUND AND ELECTROLUMINESCENCE USING THE SAME Shanghai Tianma Micro-electronics Co., Ltd. (CN) 2024-05-02 US disclosed
CN-115403608-A Spirofluorene silicon compound and electroluminescent application thereof 上海天马微电子有限公司 2022-11-29 CN disclosed
CN-102869662-B Organic electroluminescence device 默克专利有限公司 2016-08-03 CN disclosed
US-9139582-B2 Organic electroluminescent devices MERCK PATENT GMBH (DE) 2015-09-22 US disclosed
US-9139582-B2 Organic electroluminescent devices MERCK PATENT GMBH (DE) 2015-09-22 US disclosed
US-9139582-B2 Organic electroluminescent devices MERCK PATENT GMBH (DE) 2015-09-22 US disclosed
US-20130053555-A1 ORGANIC ELECTROLUMINESCENT DEVICES MERCK PATENT GMBH (DE) 2013-02-28 US disclosed
US-20130053555-A1 ORGANIC ELECTROLUMINESCENT DEVICES MERCK PATENT GMBH (DE) 2013-02-28 US disclosed
CN-102869662-A Organic electroluminescence devices MERCK PATENT GMBH 2013-01-09 CN disclosed
WO-2011137951-A1 ORGANIC ELECTROLUMINESCENCE DEVICES MERCK PATENT GMBH (DE) 2011-11-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130053555-A1 ORGANIC ELECTROLUMINESCENT DEVICES L1CAM, PIEZO1, OR10J3 ALDH1A1 183/4885MAPK1 849/4885TDP1 1215/4885
US-20240147840-A1 SPIROFLUORENE SILICON COMPOUND AND ELECTROLUMINESCENCE USING THE SAME AR, NR3C2, RPS3A ALDH1A1 1082/4885MAPK1 203/4885TDP1 4136/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.