Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | XBP1 | P17861 | 1/20 | 0.45 |
| ▸ | PLA2G2A | P14555 | 6/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
| ▸ | CD38 | P28907 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7619283 | 0.88 | PLA2G2A (0.42) | LMNAMEN1KMT2APLA2G2ACYP3A4 | |
| SCHEMBL6612458 | 0.86 | PLA2G2A (0.44) | PLA2G2AADRA1D | |
| SCHEMBL2590504 | 0.86 | CA5A (0.38) | LMNAMEN1KMT2AXBP1PLA2G2A | |
| SCHEMBL6691708 | 0.80 | LMNA (0.48) | LMNAMEN1KMT2AXBP1PLA2G2A | |
| SCHEMBL7056324 | 0.80 | ALDH1A1 (0.51) | LMNAMEN1KMT2AXBP1PLA2G2A | |
| SCHEMBL7467933 | 0.80 | RPS6KB1 (0.36) | MEN1KMT2APLA2G2AALDH1A1MAPK8 | |
| SCHEMBL7050801 | 0.79 | PLA2G2A (0.43) | LMNAMEN1KMT2APLA2G2ANPSR1 | |
| SCHEMBL7420031 | 0.79 | MAPK8 (0.41) | LMNAPLA2G2ACYP2C19CYP1A2MAPK8 | |
| SCHEMBL7050803 | 0.79 | ADRA1D (0.44) | MEN1KMT2APLA2G2AALDH1A1MAPK8 | |
| SCHEMBL7417015 | 0.79 | L3MBTL1 (0.43) | LMNAKMT2AALDH1A1HTTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102271507-A | Secreted phospholipase A2(SPLA2) Inhibitor and niacin pharmaceutical composition and method for treating cardiovascular diseases and dyslipidemia | — | 2011-12-07 | — | — | CN | disclosed |
| WO-2011137390-A1 | TREATMENT OF MAJOR ADVERSE CARDIAC EVENTS AND ACUTE CORONARY SYNDROME IN DIABETIC PATIENTS USING SECRETORY PHOSPHOLIPASE A2 (SPLA2) INHIBITOR OR SPLA2 INHIBITOR COMBINATION THERAPIES | ANTHERA PHARMACEUTICALS, INC. (US) | 2011-11-03 | — | — | WO | disclosed |
| CN-1240210-A | Substituted tricyclic compound | LILLY CO ELI (US) | 2000-01-05 | — | — | CN | disclosed |