Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NAMPT | P43490 | 6/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25308912 | 0.91 | SCD5 (0.41) | PKMSCD5TSHRALOX15USP30 | |
| SCHEMBL25427023 | 0.90 | PKM (0.42) | PKMSCD5TSHRALOX15MEN1 | |
| SCHEMBL24756985 | 0.83 | KDM4E (0.42) | PKMMEN1KMT2AMAPTGPR119 | |
| SCHEMBL21456251 | 0.82 | SCN9A (0.46) | PKMGPR119 | |
| SCHEMBL28983615 | 0.82 | TSHR (0.40) | PKMSCD5TSHRALOX15USP30 | |
| SCHEMBL25899635 | 0.81 | GABRA5 (0.39) | NAMPTUSP30GPR119 | |
| SCHEMBL30187253 | 0.81 | GPR119 (0.43) | PKMMEN1KMT2AMAPTUSP30 | |
| SCHEMBL25899721 | 0.80 | GPR119 (0.46) | MAPTUSP30GPR119 | |
| SCHEMBL25309700 | 0.79 | PKM (0.44) | PKMSCD5TSHRALOX15NAMPT | |
| SCHEMBL25308936 | 0.79 | PKM (0.44) | PKMSCD5TSHRALOX15NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023141570-A9 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF KRAS | ARVINAS OPERATIONS, INC. (US) | 2024-06-27 | — | — | WO | disclosed |
| WO-2023141570-A2 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF KRAS | ARVINAS OPERATIONS, INC. (US) | 2023-07-27 | — | — | WO | disclosed |
| CN-115803030-A | Compounds and methods for KRAS-targeted degradation | 阿维纳斯企业公司 | 2023-03-14 | — | — | CN | disclosed |
| EP-4132655-A1 | COMPOUNDS AND METHODS FOR TARGETED DEGRADATION OF KRAS | Arvinas Operations, Inc. (US) | 2023-02-15 | — | — | EP | disclosed |