Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | YAP1 | P46937 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28983614 | 0.91 | GPR119 (0.44) | GPR119PRMT5WDR77DPP4 | |
| SCHEMBL21456251 | 0.89 | SCN9A (0.46) | GPR119KDM4EYAP1PKM | |
| SCHEMBL25899721 | 0.87 | GPR119 (0.46) | GPR119ALDH1A1MAPTMAPK1NPC1 | |
| SCHEMBL24756985 | 0.86 | KDM4E (0.42) | GPR119ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL25899215 | 0.81 | PKM (0.40) | GPR119MEN1KMT2AMAPTUSP30 | |
| SCHEMBL25899635 | 0.81 | GABRA5 (0.39) | GPR119USP30 | |
| SCHEMBL25427023 | 0.80 | PKM (0.42) | GPR119MEN1KMT2AUSP30PKM | |
| SCHEMBL24461317 | 0.79 | TRPV3 (0.45) | GPR119ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL25900061 | 0.79 | CACNB4 (0.42) | GPR119USP30 | |
| SCHEMBL21673835 | 0.79 | GPR119 (0.42) | GPR119ALDH1A1MAPTMAPK1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4132655-A1 | COMPOUNDS AND METHODS FOR TARGETED DEGRADATION OF KRAS | Arvinas Operations, Inc. (US) | 2023-02-15 | — | — | EP | disclosed |