Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 3/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.38 |
| ▸ | FEN1 | P39748 | 2/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.37 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.36 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24756985 | 0.90 | KDM4E (0.42) | SCN9AALOX5APFEN1GPR119 | |
| SCHEMBL25308749 | 0.90 | GABRA5 (0.40) | GABRA5SCN9AEGLN2ALOX5APFEN1 | |
| SCHEMBL25900061 | 0.85 | CACNB4 (0.42) | GABRA5GPR119USP30 | |
| SCHEMBL21456251 | 0.84 | SCN9A (0.46) | SCN9AGPR119 | |
| SCHEMBL25899215 | 0.81 | PKM (0.40) | NAMPTGPR119USP30 | |
| SCHEMBL30187253 | 0.81 | GPR119 (0.43) | GPR119USP30 | |
| SCHEMBL24756984 | 0.80 | FAAH (0.43) | ALOX5APFEN1GPR119 | |
| SCHEMBL25427023 | 0.80 | PKM (0.42) | NAMPTGPR119USP30 | |
| SCHEMBL25899721 | 0.79 | GPR119 (0.46) | GPR119USP30 | |
| SCHEMBL25263491 | 0.79 | SCN9A (0.38) | SCN9ANAMPTGPR119USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023141570-A9 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF KRAS | ARVINAS OPERATIONS, INC. (US) | 2024-06-27 | — | — | WO | disclosed |
| WO-2023141570-A2 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF KRAS | ARVINAS OPERATIONS, INC. (US) | 2023-07-27 | — | — | WO | disclosed |