Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMPR1B | O00238 | 2/20 | 0.48 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.48 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.48 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.48 |
| ▸ | BACE1 | P56817 | 4/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | CTSC | P53634 | 4/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 2/20 | 0.35 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26021802 | 0.85 | BMPR1B (0.46) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 | |
| SCHEMBL26021793 | 0.82 | BMPR1B (0.45) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 | |
| SCHEMBL26750452 | 0.81 | BMPR1B (0.52) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 | |
| SCHEMBL26021791 | 0.80 | BMPR1B (0.51) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 | |
| SCHEMBL21011997 | 0.80 | BMPR1A (0.54) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 | |
| SCHEMBL16370734 | 0.80 | ATAD2 (0.54) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 | |
| SCHEMBL27071701 | 0.77 | BMPR1B (0.49) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 | |
| SCHEMBL8998878 | 0.77 | CASP3 (0.51) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 | |
| SCHEMBL26021776 | 0.76 | CASP3 (0.37) | BACE1CASP3BRD4ALDH1A1GAA | |
| SCHEMBL30404097 | 0.76 | HTR7 (0.54) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230265096-A1 | APOL1 INHIBITORS AND METHODS OF USE | HERCULES CAPITAL, INC., AS AGENT | 2023-08-24 | — | — | US | disclosed |
| US-20230265096-A1 | APOL1 INHIBITORS AND METHODS OF USE | HERCULES CAPITAL, INC., AS AGENT | 2023-08-24 | — | — | US | disclosed |
| WO-2023141432-A2 | APOL1 INHIBITORS AND METHODS OF USE | MAZE THERAPEUTICS, INC. (US) | 2023-07-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230265096-A1 | APOL1 INHIBITORS AND METHODS OF USE | APOL1, APOB, LDLR | BMPR1B 2037/4885BMPR1A 1194/4885TGFBR1 463/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.