Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 4/20 | 0.53 |
| ▸ | RECQL | P46063 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3374171 | 0.84 | KMO (0.71) | KMOPOLBRECQLNPC1RAB9A | |
| SCHEMBL29544889 | 0.84 | KMO (0.71) | KMOPOLBRECQLNPC1RAB9A | |
| SCHEMBL8889255 | 0.83 | KMO (0.74) | KMOPOLBRECQLNPC1RAB9A | |
| SCHEMBL27733623 | 0.83 | NPC1 (0.56) | KMOPOLBRECQLNPC1RAB9A | |
| SCHEMBL8999792 | 0.83 | KMO (0.59) | KMOPOLBRECQLNPC1RAB9A | |
| SCHEMBL28736790 | 0.82 | KMO (0.68) | KMOPOLBRECQLNPC1RAB9A | |
| SCHEMBL38656843 | 0.82 | NPC1 (0.59) | KMOPOLBRECQLNPC1RAB9A | |
| SCHEMBL27733621 | 0.81 | NPC1 (0.54) | KMOPOLBRECQLNPC1RAB9A | |
| SCHEMBL13978502 | 0.80 | KMO (0.43) | KMOPOLBRECQLNPC1RAB9A | |
| SCHEMBL12892436 | 0.80 | POLB (0.56) | KMOPOLBRECQLNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110396089-A | Target compound and the application of kidney type glutaminase allosteric site | HANGZHOU JIANNIFU BIOLOGICAL TECH CO LTD | 2019-11-01 | — | — | CN | claimed |
| WO-2011138265-A2 | INDOLE AND INDAZOLE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | claimed |
| CN-111590988-B | Processing method of NY/RCPP composite film for high-temperature steaming bag | 合肥佛斯德新材料科技有限公司 | 2022-04-01 | — | — | CN | disclosed |
| CN-111590988-A | Processing method of NY/RCPP composite film for high-temperature steaming bag | 合肥佛斯德新材料科技有限公司 | 2020-08-28 | — | — | CN | disclosed |
| CN-110396089-A | Target compound and the application of kidney type glutaminase allosteric site | HANGZHOU JIANNIFU BIOLOGICAL TECH CO LTD | 2019-11-01 | — | — | CN | disclosed |
| US-8648076-B2 | Cysteine protease inhibitors and their therapeutic applications | HYBRIGENICS SA (FR) | 2014-02-11 | — | — | US | disclosed |
| CN-102260214-B | Method for preparing indazole compound | UNIV ZHEJIANG | 2013-12-04 | — | — | CN | disclosed |
| CN-102260214-B | Method for preparing indazole compound | UNIV ZHEJIANG | 2013-12-04 | — | — | CN | disclosed |
| CN-101747277-B | Application and preparation of indazole compound | UNIV ZHEJIANG | 2012-01-25 | — | — | CN | disclosed |
| CN-101747277-B | Application and preparation of indazole compound | UNIV ZHEJIANG | 2012-01-25 | — | — | CN | disclosed |
| CN-102260214-A | Method for preparing indazole compound | — | 2011-11-30 | — | — | CN | disclosed |
| CN-101747277-A | Application and preparation of indazole compound | UNIV ZHEJIANG | 2010-06-23 | — | — | CN | disclosed |
| US-20090270391-A1 | THIENOPYRIDINE DERIVATIVE, OR QUINOLINE DERIVATIVE, OR QUINAZOLINE DERIVATIVE, HAVING c-MET AUTOPHOSPHORYLATION INHIBITING POTENCY | KIRIN PHARMA KABUSHIKI KAISHA (JP) | 2009-10-29 | — | — | US | disclosed |
| US-20090270391-A1 | THIENOPYRIDINE DERIVATIVE, OR QUINOLINE DERIVATIVE, OR QUINAZOLINE DERIVATIVE, HAVING c-MET AUTOPHOSPHORYLATION INHIBITING POTENCY | KIRIN PHARMA KABUSHIKI KAISHA (JP) | 2009-10-29 | — | — | US | disclosed |
| US-20090270391-A1 | THIENOPYRIDINE DERIVATIVE, OR QUINOLINE DERIVATIVE, OR QUINAZOLINE DERIVATIVE, HAVING c-MET AUTOPHOSPHORYLATION INHIBITING POTENCY | KIRIN PHARMA KABUSHIKI KAISHA (JP) | 2009-10-29 | — | — | US | disclosed |
| US-20090215786-A1 | NOVEL CYSTEINE PROTEASE INHIBITORS AND THEIR THERAPEUTIC APPLICATIONS | HYBRIGENICS SA (FR) | 2009-08-27 | — | — | US | disclosed |
| CN-101189241-A | Thienopyridine derivative, quinoline derivative, and quinazoline derivative having c-Met autophosphorylation inhibiting activity | KIRIN PHARMA KK (JP) | 2008-05-28 | — | — | CN | disclosed |
| EP-1870414-A1 | THIENOPYRIDINE DERIVATIVE, OR QUINOLINE DERIVATIVE, OR QUINAZOLINE DERIVATIVE, HAVING C-MET AUTOPHOSPHORYLATION INHIBITING POTENCY | Kirin Pharma Kabushiki Kaisha (JP) | 2007-12-26 | — | — | EP | disclosed |
| US-20070032499-A1 | Novel cysteine protease inhibitors and their therapeutic applications | HYBRIGENICS SA (FR) | 2007-02-08 | — | — | US | disclosed |
| WO-2007008514-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | GEORGETOWN UNIVERSITY (US) | 2007-01-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032499-A1 | Novel cysteine protease inhibitors and their therapeutic applications | SERPINB1, CTSF, CTSE | KMO 4653/4885POLB 4100/4885RECQL 3852/4885 |
| US-20090270391-A1 | THIENOPYRIDINE DERIVATIVE, OR QUINOLINE DERIVATIVE, OR QUINAZOLINE DERIVATIVE, HAVING c-MET AUTOPHOSPHORYLATION INHIBITING POTENCY | MET, ABL1, RET | KMO 1635/4885POLB 4415/4885RECQL 1287/4885 |
| US-20090215786-A1 | NOVEL CYSTEINE PROTEASE INHIBITORS AND THEIR THERAPEUTIC APPLICATIONS | SERPINB1, CTSF, CTSE | KMO 4653/4885POLB 4100/4885RECQL 3852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.