Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CUL4A | Q13619 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12186618 | 0.80 | MAPK14 (0.42) | PDE10AMAPK14KDM4EALDH1A1GAA | |
| SCHEMBL12186595 | 0.80 | MAPK14 (0.42) | PDE10AMAPK14KDM4EALDH1A1HPGD | |
| SCHEMBL13148102 | 0.77 | PDE10A (0.58) | PDE10AKDM4EALDH1A1HPGDGLA | |
| SCHEMBL2598152 | 0.68 | RIPK2 (0.42) | ALDH1A1ADORA1ADORA2APIM1PTGES | |
| SCHEMBL3063545 | 0.65 | METAP2 (0.58) | MAPK14ALDH1A1GAAPTGESMET | |
| SCHEMBL5743717 | 0.64 | CUL4A (0.40) | PDE10AKDM4EALDH1A1HPGDGAA | |
| SCHEMBL28843463 | 0.64 | POLB (0.54) | PDE10AKDM4EALDH1A1HPGDGLA | |
| SCHEMBL30320037 | 0.64 | GABRA1 (0.53) | KDM4EALDH1A1HPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL2391060 | 0.64 | GABRA1 (0.53) | KDM4EALDH1A1HPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL28318559 | 0.63 | NPC1 (0.45) | KDM4EALDH1A1GAAHSD17B10PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815858-B2 | Heterocyclic flaviviridae virus inhibitors | GILEAD SCIENCES, INC. (US) | 2014-08-26 | — | — | US | disclosed |
| US-8815858-B2 | Heterocyclic flaviviridae virus inhibitors | GILEAD SCIENCES, INC. (US) | 2014-08-26 | — | — | US | disclosed |
| US-8815858-B2 | Heterocyclic flaviviridae virus inhibitors | GILEAD SCIENCES, INC. (US) | 2014-08-26 | — | — | US | disclosed |
| US-20130171102-A1 | HETEROCYCLIC FLAVIVIRIDAE VIRUS INHIBITORS | GILEAD SCIENCES, INC. (US) | 2013-07-04 | — | — | US | disclosed |
| US-20130171102-A1 | HETEROCYCLIC FLAVIVIRIDAE VIRUS INHIBITORS | GILEAD SCIENCES, INC. (US) | 2013-07-04 | — | — | US | disclosed |
| US-20130171102-A1 | HETEROCYCLIC FLAVIVIRIDAE VIRUS INHIBITORS | GILEAD SCIENCES, INC. (US) | 2013-07-04 | — | — | US | disclosed |
| EP-2571882-A1 | HETEROCYCLIC FLAVIVIRIDAE VIRUS INHIBITORS | Gilead Sciences, Inc. (US) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011146817-A1 | HETEROCYCLIC FLAVIVIRIDAE VIRUS INHIBITORS | GILEAD SCIENCES, INC. (US) | 2011-11-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130171102-A1 | HETEROCYCLIC FLAVIVIRIDAE VIRUS INHIBITORS | EIF2AK2, MAVS, ZC3HAV1 | PDE10A 3528/4885MAPK14 1753/4885KDM4E 1201/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.