Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.61 |
| ▸ | NPC1 | O15118 | 4/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | GSK3B | P49841 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | RECQL | P46063 | 2/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | APEX1 | P27695 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.54 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.53 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1861084 | 0.84 | RAB9A (0.58) | RAB9ANPC1MAPTALDH1A1MAPK1 | |
| SCHEMBL7079689 | 0.83 | RAB9A (0.66) | RAB9ANPC1MAPTALDH1A1MAPK1 | |
| SCHEMBL450084 | 0.83 | RAB9A (0.85) | RAB9ANPC1MAPTALDH1A1MAPK1 | |
| SCHEMBL19924831 | 0.82 | ALDH1A1 (0.53) | RAB9ANPC1MAPTGSK3BALDH1A1 | |
| SCHEMBL11480265 | 0.82 | GSK3B (0.80) | RAB9ANPC1MAPTGSK3BALDH1A1 | |
| SCHEMBL2240591 | 0.81 | NPC1 (0.54) | RAB9ANPC1MAPTALDH1A1MAPK1 | |
| SCHEMBL965418 | 0.81 | RAB9A (0.63) | RAB9ANPC1MAPTALDH1A1MAPK1 | |
| SCHEMBL5874076 | 0.81 | RAB9A (0.63) | RAB9ANPC1MAPTALDH1A1MAPK1 | |
| SCHEMBL8521146 | 0.80 | RAB9A (0.58) | RAB9ANPC1MAPTALDH1A1MAPK1 | |
| SCHEMBL10471481 | 0.80 | NPC1 (0.53) | RAB9ANPC1MAPTALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 87 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114539040-B | Method for synthesizing alpha-halogenated ketone compound by photocatalysis | 苏州大学张家港工业技术研究院 | 2023-06-23 | — | — | CN | disclosed |
| CN-116023202-A | Synthetic method of alpha-chlorarone derivative | 西南大学 | 2023-04-28 | — | — | CN | disclosed |
| US-11584742-B2 | Substituted aminothiazoles as inhibitors of nucleases | MASARYKOVA UNIVERZITA (CZ) | 2023-02-21 | — | — | US | disclosed |
| CN-114539040-A | Method for synthesizing alpha-haloketone compound by photocatalysis | 苏州大学张家港工业技术研究院 | 2022-05-27 | — | — | CN | disclosed |
| US-20220002282-A1 | SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES | MASARYKOVA UNIVERZITA (CZ) | 2022-01-06 | — | — | US | disclosed |
| EP-3556755-B1 | SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES | UNIV MASARYKOVA (CZ) | 2021-11-17 | — | — | EP | disclosed |
| CN-107068574-B | Semiconductor device and method | 台湾积体电路制造股份有限公司 | 2020-06-05 | — | — | CN | disclosed |
| WO-2019201865-A1 | SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES | MASARYKOVA UNIVERZITA (CZ) | 2019-10-24 | — | — | WO | disclosed |
| EP-3556755-A1 | SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES | Masarykova univerzita (CZ) | 2019-10-23 | — | — | EP | disclosed |
| US-10004701-B2 | Methods and compositions for treating infection | UNIVERSITY OF ROCHESTER (US) | 2018-06-26 | — | — | US | disclosed |
| EP-0512352-B1 | Substituted carboxylic acid derivatives | HOFFMANN LA ROCHE (CH) | 1996-03-27 | — | — | EP | disclosed |
| EP-0696280-A1 | SUBSTITUTED PYRROLIDIN-3-YL-ALKYL-PIPERIDINES USEFUL AS TACHYKININ ANTAGONISTS | MERRELL DOW PHARMA (US) | 1996-02-14 | — | — | EP | disclosed |
| EP-0681225-A1 | Electrostatic toner comprising phenacyl compounds | BASF AKTIENGESELLSCHAFT (DE) | 1995-11-08 | — | — | EP | disclosed |
| WO-1994026735-A1 | SUBSTITUTED PYRROLIDIN-3-YL-ALKYL-PIPERIDINES USEFUL AS TACHYKININ ANTAGONISTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-11-24 | — | — | WO | disclosed |
| US-5344843-A | Carnitine acryltransferase enzyme inhibitors as antiischemic agents and for cardiovascular disorders | HOFFMAN-LA ROCHE INC. (US) | 1994-09-06 | — | — | US | disclosed |
| EP-0512352-A2 | Substituted carboxylic acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1992-11-11 | — | — | EP | disclosed |
| US-4293636-A | HALF ESTER OF HYDROXYALKYL ACRYLATE AND POLYBASIC ACID, VINYL MONOMER | TAMURA KAKEN CO., LTD. (JP) | 1981-10-06 | — | — | US | disclosed |
| US-4115224-A | PHENOL, UREA, MELAMINE RESINS | AKZO NV (NL) | 1978-09-19 | — | — | US | disclosed |
| US-RE29153-E | HERBICIDES, INSECTICIDES | MONSANTO COMPANY (US) | 1977-03-15 | — | — | US | disclosed |
| US-4001098-A | UNSATURATED POLYESTER | AKZONA INCORPORATED (US) | 1977-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11584742-B2 | Substituted aminothiazoles as inhibitors of nucleases | RNASEH1, DNASE1, FEN1 | RAB9A 2879/4885NPC1 3091/4885MAPT 706/4885 |
| US-20220002282-A1 | SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES | RNASEH1, DNASE1, FEN1 | RAB9A 2879/4885NPC1 3091/4885MAPT 706/4885 |
| US-10004701-B2 | Methods and compositions for treating infection | MMP8, IFNG, MPO | RAB9A 3512/4885NPC1 1447/4885MAPT 4152/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.