Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HPGDS | O60760 | 2/20 | 0.49 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.48 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.48 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.46 |
| ▸ | GPR39 | O43194 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1018033 | 0.89 | ALB (0.49) | ALDH1A1HPGDSCXCR1CXCR2 | |
| SCHEMBL12727155 | 0.89 | HPGDS (0.49) | ALDH1A1HPGDSCXCR1CXCR2HDAC1 | |
| SCHEMBL26033188 | 0.86 | MAPK14 (0.50) | ALDH1A1KIF18ANPC1RAB9A | |
| SCHEMBL26033207 | 0.86 | HCAR3 (0.49) | KIF18ANPC1RAB9AKMT2A | |
| SCHEMBL26033613 | 0.86 | HCAR3 (0.51) | ALDH1A1KIF18AKMT2A | |
| SCHEMBL26033252 | 0.85 | HDAC1 (0.53) | GPR39HDAC1NPC1RAB9AKMT2A | |
| SCHEMBL26033666 | 0.85 | KIF18A (0.45) | KIF18ARAB9A | |
| SCHEMBL26037196 | 0.82 | HPGD (0.48) | ALDH1A1KIF18ARAB9AKMT2A | |
| SCHEMBL26035124 | 0.81 | RAB9A (0.57) | RAB9AKMT2A | |
| SCHEMBL26033211 | 0.80 | RIPK1 (0.52) | ALDH1A1HPGDSKIF18A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230265054-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | GENENTECH, INC. (US) | 2023-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230265054-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | SHH, GLI1, SMO | ALDH1A1 2407/4885HPGDS 1126/4885CXCR1 603/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.