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SCHEMBL260584

SCHEMBL260584

NC(=S)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1

nearest known ligand 0.59

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ KIF11 P52732 1/20 0.59
▸ MAPT P10636 4/20 0.52
▸ LMNA P02545 1/20 0.51
▸ GAA P10253 1/20 0.51
▸ KDM4E B2RXH2 2/20 0.50
▸ MEN1 O00255 3/20 0.49
▸ KMT2A Q03164 3/20 0.49
▸ MYC P01106 1/20 0.49
▸ MAX P61244 1/20 0.49
▸ GPR35 Q9HC97 1/20 0.48
▸ P2RX1 P51575 2/20 0.47
▸ IDO1 P14902 1/20 0.46
▸ ACP1 P24666 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16342082 0.87 KIF11 (0.51) KIF11MAPTLMNAGAAGPR35
SCHEMBL27264663 0.87 P2RX4 (0.53) KIF11MAPTLMNAGAAKDM4E
SCHEMBL13301012 0.83 MAPT (0.56) MAPTLMNAGAAKDM4EMEN1
SCHEMBL11009249 0.83 MAPT (0.67) MAPTLMNAGAAKDM4EMEN1
SCHEMBL230618 0.81 IDO1 (0.71) MAPTLMNAGAAKDM4EMEN1
SCHEMBL5438060 0.80 IDO1 (0.70) MAPTLMNAGAAKDM4EMEN1
SCHEMBL23540359 0.80 KIF11 (0.51) KIF11MAPTGAAKDM4EMEN1
SCHEMBL6985227 0.80 IDO1 (0.69) MAPTLMNAGAAKDM4EMEN1
SCHEMBL30042197 0.80 KIF11 (0.51) KIF11MAPTGAAKDM4EMEN1
SCHEMBL11594274 0.79 MAPT (0.52) MAPTLMNAGAAKDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119798105-A Preparation method of milabalin 长治医学院 2025-04-11 — — CN claimed
CN-118825418-A Low-temperature electrolyte suitable for lithium/sodium ion battery 哈尔滨工业大学 2024-10-22 — — CN claimed
CN-110713582-B Preparation method of copolyester polyurethane 华中科技大学 2021-06-11 — — CN claimed
CN-108147973-B Preparation method of N- [1- (S) -ethoxycarbonyl-3-phenylpropyl ] -L-alanine 凯莱英医药集团（天津）股份有限公司 2021-04-06 — — CN claimed
CN-110713582-A Preparation method of copolyester polyurethane 华中科技大学 2020-01-21 — — CN claimed
EP-1753734-A1 NITRIC OXIDE DONORS AND USES THEREOF RENOPHARM LTD. (IL) 2007-02-21 — — EP claimed
WO-2005105765-A1 NITRIC OXIDE DONORS AND USES THEREOF RENOPHARM LTD. (IL) 2005-11-10 — — WO claimed
CN-119798105-A Preparation method of milabalin 长治医学院 2025-04-11 — — CN disclosed
US-20250051314-A1 SMALL MOLECULE INHIBITORS OF INTERFERON GAMMA SIGNALING PARIS SCIENCES ET LETTRES (FR) 2025-02-13 — — US disclosed
CN-118825418-A Low-temperature electrolyte suitable for lithium/sodium ion battery 哈尔滨工业大学 2024-10-22 — — CN disclosed
EP-4444308-A1 SMALL MOLECULE INHIBITORS OF INTERFERON GAMMA SIGNALING Institut Curie (FR) 2024-10-16 — — EP disclosed
CN-118027007-A 3-Indole or pyrrolyl-2-nitroolefin saccharide compound, and preparation method and application thereof 中国科学院成都生物研究所 2024-05-14 — — CN disclosed
CN-117229491-A Method for preparing polylactic acid by using organic alkali thiourea double-catalytic system 苏州大学 2023-12-15 — — CN disclosed
US-20070021382-A1 Nitric oxide donors and uses thereof RENOPHARM LTD. (IL) 2007-01-25 — — US disclosed
US-20060183718-A1 Thiazole-based nitric oxide donors having aryl substituent(s) and uses thereof RENOPHARM LTD. (IL) 2006-08-17 — — US disclosed
US-20060183913-A1 Thiazole-based nitric oxide donors having acyl substuent(s) and uses thereof RENOPHARM LTD. (IL) 2006-08-17 — — US disclosed
US-20060183912-A1 Thiazole-based nitric oxide donors having at least two thiazole moieties and uses thereof RENOPHARM LTD. (IL) 2006-08-17 — — US disclosed
US-20060069139-A1 Thiazole-based nitric oxide donors capable of releasing two or more nitric oxide molecules and uses thereof RENOPHARM LTD. (IL) 2006-03-30 — — US disclosed
US-20060069138-A1 Thiazole-based nitric oxide donors having alkyl substuent(s) and uses thereof RENOPHARM LTD. (IL) 2006-03-30 — — US disclosed
WO-2005105765-A1 NITRIC OXIDE DONORS AND USES THEREOF RENOPHARM LTD. (IL) 2005-11-10 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060183912-A1 Thiazole-based nitric oxide donors having at least two thiazole moieties and uses thereof NOS2, NOS1, NOS3 KIF11 4512/4885MAPT 3098/4885LMNA 4357/4885
US-20060183718-A1 Thiazole-based nitric oxide donors having aryl substituent(s) and uses thereof NOS2, NOS1, NOS3 KIF11 4546/4885MAPT 4152/4885LMNA 4412/4885
US-20250051314-A1 SMALL MOLECULE INHIBITORS OF INTERFERON GAMMA SIGNALING STAT1, IFNG, IRF2BP2 KIF11 3479/4885MAPT 4087/4885LMNA 4746/4885
US-20060183913-A1 Thiazole-based nitric oxide donors having acyl substuent(s) and uses thereof NOS2, NOS1, SQOR KIF11 4512/4885MAPT 4020/4885LMNA 4210/4885
US-20060069139-A1 Thiazole-based nitric oxide donors capable of releasing two or more nitric oxide molecules and uses thereof NOS2, NOS1, NOS3 KIF11 4692/4885MAPT 3663/4885LMNA 4082/4885
US-20070021382-A1 Nitric oxide donors and uses thereof NOS2, NOS1, NOS3 KIF11 4792/4885MAPT 4219/4885LMNA 3973/4885
US-20060069138-A1 Thiazole-based nitric oxide donors having alkyl substuent(s) and uses thereof NOS1, NOS2, NOS3 KIF11 4607/4885MAPT 4115/4885LMNA 3851/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.