Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | FDPS | P14324 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2606357 | 1.00 | ALOX5 (0.41) | ALOX5EPHX1ALDH1A1HTTTSHR | |
| SCHEMBL2606475 | 0.85 | ALOX5 (0.37) | ALOX5EPHX1ALDH1A1HTTL3MBTL1 | |
| SCHEMBL11051370 | 0.74 | KDM4E (0.38) | ALOX5HTTTSHRHPGDSMN1; SMN2 | |
| SCHEMBL1874083 | 0.74 | SIGMAR1 (0.37) | — | |
| SCHEMBL27915666 | 0.74 | HTT (0.49) | EPHX1ALDH1A1HTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL4646750 | 0.72 | ADH1C (0.36) | ALDH1A1TSHRSMN1; SMN2FDPS | |
| SCHEMBL4435493 | 0.71 | L3MBTL1 (0.39) | ALOX5ALDH1A1HTTHPGDL3MBTL1 | |
| SCHEMBL2606404 | 0.69 | ALOX5 (0.45) | ALOX5EPHX1TSHR | |
| SCHEMBL11234464 | 0.69 | ALOX5 (0.45) | ALOX5EPHX1TSHR | |
| SCHEMBL2754 | 0.69 | ALOX5 (0.45) | ALOX5EPHX1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2444397-A1 | Heteroaryl-ureas and their use as glucokinase activators | Novo Nordisk A/S (DK) | 2012-04-25 | — | — | EP | disclosed |
| WO-2005066145-A1 | HETEROARYL-UREAS AND THEIR USE AS GLUCOKINASE ACTIVATORS | NOVO NORDISK A/S (DK) | 2005-07-21 | — | — | WO | disclosed |