Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ABHD6 | Q9BV23 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11051370 | 0.91 | KDM4E (0.38) | ALOX5MAPTKMT2AKDM4EHTT | |
| SCHEMBL2606340 | 0.85 | ALOX5 (0.41) | ALOX5ALDH1A1L3MBTL1HTTEPHX1 | |
| SCHEMBL2606357 | 0.85 | ALOX5 (0.41) | ALOX5ALDH1A1L3MBTL1HTTEPHX1 | |
| SCHEMBL10912372 | 0.75 | ALDH1A1 (0.48) | ALDH1A1MAPTKMT2AL3MBTL1ABHD6 | |
| SCHEMBL21437424 | 0.71 | MAPT (0.35) | ALDH1A1MAPTKMT2AABHD6KDM4E | |
| SCHEMBL2667242 | 0.71 | KMT2A (0.47) | ALDH1A1MAPTKMT2AKDM4ENPSR1 | |
| SCHEMBL2606412 | 0.71 | S1PR3 (0.47) | ALOX5KMT2AKDM4ELMNAEPHX1 | |
| SCHEMBL1305041 | 0.69 | GAA (0.38) | ALDH1A1MAPTKMT2AKDM4EHTT | |
| SCHEMBL28136187 | 0.68 | LMNA (0.37) | ALDH1A1MAPTKMT2AABHD6KDM4E | |
| SCHEMBL155479 | 0.68 | ALDH1A1 (0.45) | ALDH1A1MAPTKMT2AKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2444397-A1 | Heteroaryl-ureas and their use as glucokinase activators | Novo Nordisk A/S (DK) | 2012-04-25 | — | — | EP | disclosed |