SCHEMBL2607906

SCHEMBL2607906

O=S(=O)(CCO)CC(F)(F)F

nearest known ligand 0.35

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CES1 P23141 4/20 0.35
ATR Q13535 1/20 0.35
CA12 O43570 1/20 0.30
CA1 P00915 1/20 0.30
CA2 P00918 1/20 0.30
CA3 P07451 1/20 0.30
CA4 P22748 1/20 0.30
CA6 P23280 1/20 0.30
CA5A P35218 1/20 0.30
CA7 P43166 1/20 0.30
CA9 Q16790 1/20 0.30
CA13 Q8N1Q1 1/20 0.30
CA14 Q9ULX7 1/20 0.30
CA5B Q9Y2D0 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11136058 0.78
SCHEMBL7051925 0.78
SCHEMBL777742 0.76 CA1 (0.35) CA1CA2CA7CA9CA13
SCHEMBL7054561 0.76 CES1 (0.32) CES1
SCHEMBL776785 0.76 CES1 (0.32) CES1
SCHEMBL11897704 0.74 CES1 (0.44) CES1
SCHEMBL21799432 0.74 CES1 (0.31) CES1
SCHEMBL11929447 0.74 LMNA (0.38) CES1CA1CA2CA7CA9
SCHEMBL10786838 0.74 NOS2 (0.32) CES1ATR
SCHEMBL12833421 0.74 CES1 (0.31) CES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180207286-A1 CONJUGATES OF A CHOLINESTERASE MOIETY AND A POLYMER NEKTAR THERAPEUTICS 2018-07-26 US disclosed
US-20180085468-A1 CONJUGATES OF AN IL-2 MOIETY AND A POLYMER NEKTAR THERAPEUTICS 2018-03-29 US disclosed
US-9763995-B2 Polymer conjugates of protegrin peptides NEKTAR THERAPEUTICS (US) 2017-09-19 US disclosed
US-20170196975-A1 CONJUGATES OF AN ANTI-TNF-ALPHA ANTIBODY NEKTAR THERAPEUTICS 2017-07-13 US disclosed
US-9682153-B2 Polymer conjugates of therapeutic peptides NEKTAR THERAPEUTICS (US) 2017-06-20 US disclosed
US-9636412-B2 Conjugates of an anti-TNF-alpha antibody NEKTAR THERAPEUTICS (US) 2017-05-02 US disclosed
US-20170035896-A1 POLYMER FACTOR IX MOIETY CONJUGATES NEKTAR THERAPEUTICS 2017-02-09 US disclosed
US-9433684-B2 Conjugates of small-interfering nucleic acids NEKTAR THERAPEUTICS (US) 2016-09-06 US disclosed
US-9421275-B2 Oligomer-calcimimetic conjugates and related compunds NEKTAR THERAPEUTICS (US) 2016-08-23 US disclosed
US-20160158311-A1 POLYMER CONJUGATES OF PROTEGRIN PEPTIDES NEKTAR THERAPEUTICS 2016-06-09 US disclosed
US-20110171165-A1 POLYMER CONJUGATES OF OPIOID GROWTH FACTOR PEPTIDES NEKTAR THERAPEUTICS 2011-07-14 US disclosed
US-20110171160-A1 POLYMER CONJUGATES OF KISS1 PEPTIDES NEKTAR THERAPEUTICS (US) 2011-07-14 US disclosed
US-20110165111-A1 POLYMER CONJUGATES OF NESIRITIDE PEPTIDES NEKTAR THERAPEUTICS (US) 2011-07-07 US disclosed
US-20110165113-A1 POLYMER CONJUGATES OF V681-LIKE PEPTIDES NEKTAR THERAPEUTICS (US) 2011-07-07 US disclosed
US-20110165112-A1 POLYMER CONJUGATES OF C-PEPTIDES NEKTAR THERAPEUTICS (US) 2011-07-07 US disclosed
US-20110135623-A1 Conjugates of a Cholinesterase Moiety and a Polymer NEKTAR THERAPEUTICS (US) 2011-06-09 US disclosed
US-20100021481-A1 CONJUGATES OF AN ANTI-TNF-ALPHA ANTIBODY NEKTAR THERAPEUTICS (US) 2010-01-28 US disclosed
EP-0882715-B1 NOVEL N-(UNSUBSTITUTED OR SUBSTITUTED)-4-SUBSTITUTED-6-(UNSUBSTITUTED OR SUBSTITUTED)PHENOXY-2-PYRIDINECARBOXAMIDES OR THIOCARBOXAMIDES, PROCESSES FOR PRODUCING THE SAME, AND HERBICIDES KUREHA CHEMICAL IND CO LTD (JP) 2003-04-23 EP disclosed
US-6339045-B1 CAN BE USED IN A SMALL AMOUNT, SHOWING A GOOD SELECTIVITY BETWEEN CROP AND WEED, AND CAUSING NO PHYTOTOXICITY KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 2002-01-15 US disclosed
EP-0882715-A1 NOVEL N-(UNSUBSTITUTED OR SUBSTITUTED)-4-SUBSTITUTED-6-(UNSUBSTITUTED OR SUBSTITUTED)PHENOXY-2-PYRIDINECARBOXAMIDES OR THIOCARBOXAMIDES, PROCESSES FOR PRODUCING THE SAME, AND HERBICIDES KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1998-12-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110171160-A1 POLYMER CONJUGATES OF KISS1 PEPTIDES KISS1R, PROKR1, NGLY1 CES1 2573/4885ATR 4407/4885CA12 1255/4885
US-20110135623-A1 Conjugates of a Cholinesterase Moiety and a Polymer BCHE, ACHE, DNPEP CES1 9/4885ATR 3810/4885CA12 57/4885
US-20170035896-A1 POLYMER FACTOR IX MOIETY CONJUGATES F9, F13A1, F8 CES1 2418/4885ATR 4166/4885CA12 574/4885
US-20100021481-A1 CONJUGATES OF AN ANTI-TNF-ALPHA ANTIBODY TNF, TNFRSF1A, TNFRSF9 CES1 700/4885ATR 3936/4885CA12 930/4885
US-20170196975-A1 CONJUGATES OF AN ANTI-TNF-ALPHA ANTIBODY TNF, TNFRSF1A, TNFRSF9 CES1 670/4885ATR 3944/4885CA12 842/4885
US-20110165111-A1 POLYMER CONJUGATES OF NESIRITIDE PEPTIDES NGLY1, IAPP, NPSR1 CES1 2324/4885ATR 4413/4885CA12 1622/4885
US-20110165112-A1 POLYMER CONJUGATES OF C-PEPTIDES IAPP, GCG, INSR CES1 1247/4885ATR 4690/4885CA12 398/4885
US-20160158311-A1 POLYMER CONJUGATES OF PROTEGRIN PEPTIDES PSMG3, PSMB11, UBQLN1 CES1 4422/4885ATR 4139/4885CA12 3608/4885
US-20180085468-A1 CONJUGATES OF AN IL-2 MOIETY AND A POLYMER IL2, IL2RA, ILF2 CES1 3073/4885ATR 4853/4885CA12 895/4885
US-20180207286-A1 CONJUGATES OF A CHOLINESTERASE MOIETY AND A POLYMER BCHE, ACHE, DNPEP CES1 8/4885ATR 3830/4885CA12 62/4885
US-20110165113-A1 POLYMER CONJUGATES OF V681-LIKE PEPTIDES NGLY1, VIP, DNPEP CES1 3736/4885ATR 4631/4885CA12 991/4885
US-20110171165-A1 POLYMER CONJUGATES OF OPIOID GROWTH FACTOR PEPTIDES OGFR, OGFRL1, OPRL1 CES1 4116/4885ATR 4806/4885CA12 1292/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.