Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 9/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13222201 | 0.84 | ALDH1A1 (0.70) | GSK3BPTPN1ALDH1A1KMT2APOLB | |
| SCHEMBL11533429 | 0.82 | CYP2C9 (0.65) | ALDH1A1KMT2APOLBMAPTRAB9A | |
| SCHEMBL26113192 | 0.81 | CYP1A2 (0.58) | ALDH1A1KMT2APOLBMAPTRAB9A | |
| SCHEMBL17978815 | 0.80 | CYP2C9 (0.55) | KMT2ARAB9ACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL7314826 | 0.80 | KMT2A (0.71) | ALDH1A1KMT2ACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL16162038 | 0.77 | EPHX2 (0.58) | KMT2APOLBMAPTCYP1A2CYP2D6 | |
| SCHEMBL22833169 | 0.77 | KMT2A (0.52) | ALDH1A1KMT2APOLBMAPTRAB9A | |
| SCHEMBL26112506 | 0.77 | KMT2A (0.61) | ALDH1A1KMT2APOLBMAPTRAB9A | |
| SCHEMBL205280 | 0.77 | GSK3B (0.80) | GSK3BPTPN1RAB9AHDAC1HDAC6 | |
| SCHEMBL1694370 | 0.76 | L3MBTL1 (0.62) | ALDH1A1KMT2APOLBMAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230322667-A1 | DIHYDROFOLATE SYNTHASE (DHFS) INHIBITING AGENTS AND METHODS OF MAKING AND USING SAME | WASHINGTON UNIVERSITY (US) | 2023-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230322667-A1 | DIHYDROFOLATE SYNTHASE (DHFS) INHIBITING AGENTS AND METHODS OF MAKING AND USING SAME | DHFR, DHPS, MTHFD1 | GSK3B 3565/4885PTPN1 4411/4885ALDH1A1 702/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.