SCHEMBL26134331

SCHEMBL26134331

O=C(O)c1ccn(CCF)c1

nearest known ligand 0.47

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
AKR1B1 P15121 1/20 0.43
CNR1 P21554 1/20 0.38
PLA2G4A P47712 1/20 0.36
TSHR P16473 2/20 0.36
TP53 P04637 1/20 0.36
TBXAS1 P24557 5/20 0.33
DAO P14920 1/20 0.33
NAPRT Q6XQN6 1/20 0.33
CCNC P24863 1/20 0.33
CDK8 P49336 1/20 0.33
ALDH1A1 P00352 1/20 0.33
HPGD P15428 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
SRD5A2 P31213 1/20 0.32
MEN1 O00255 1/20 0.32
LMNA P02545 1/20 0.32
KMT2A Q03164 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22748727 0.86 CNR1 (0.40) AKR1B1CNR1PLA2G4ATBXAS1
SCHEMBL30098901 0.83 AKR1B1 (0.39) AKR1B1CNR1TSHRTBXAS1CCNC
SCHEMBL3261973 0.81 AKR1B1 (0.41) AKR1B1CNR1PLA2G4ATSHRTP53
SCHEMBL7755595 0.81 KDM5A (0.48) AKR1B1CNR1PLA2G4ATSHRTP53
SCHEMBL24852823 0.79 LOXL2 (0.42) CNR1TSHRMEN1LMNAKMT2A
SCHEMBL29132913 0.78 PLA2G4A (0.43) AKR1B1CNR1PLA2G4AALDH1A1HPGD
SCHEMBL22063999 0.77 ALDH1A1 (0.47) AKR1B1PLA2G4ATBXAS1ALDH1A1MEN1
SCHEMBL969727 0.76 AKR1B1 (0.46) AKR1B1CNR1PLA2G4ATSHRTP53
SCHEMBL21413172 0.75 CNR1 (0.56) CNR1PLA2G4ATSHRTP53ALDH1A1
SCHEMBL9150323 0.75 CNR1 (0.56) CNR1PLA2G4ATSHRTP53ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12275707-B2 Modulators of mas-related g-protein receptor X2 and related products and methods ESCIENT PHARMACEUTICALS, INC. (US) 2025-04-15 US disclosed
EP-4499632-A1 QUINOLINE DERIVATIVES AS MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS ESCIENT PHARMACEUTICALS, INC. (US) 2025-02-05 EP disclosed
US-20250026735-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS INCYTE CORPORATION 2025-01-23 US disclosed
CN-119095839-A Quinoline derivatives as modulators and related products of Mas-associated G protein receptor X2 伊赛恩特制药公司 2024-12-06 CN disclosed
US-12129243-B2 Modulators of Mas-related G-protein receptor X2 and related products and methods ESCIENT PHARMACEUTICALS, INC. (US) 2024-10-29 US disclosed
US-12129244-B2 Modulators of Mas-related G-protein receptor X2 and related products and methods ESCIENT PHARMACEUTICALS, INC. (US) 2024-10-29 US disclosed
US-20240336570-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS ESCIENT PHARMACEUTICALS INC (US) 2024-10-10 US disclosed
US-20240124416-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS INCYTE CORPORATION 2024-04-18 US disclosed
US-20240124415-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS INCYTE CORPORATION 2024-04-18 US disclosed
US-20240124414-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS INCYTE CORPORATION 2024-04-18 US disclosed
US-11919864-B2 Modulators of Mas-related G-protein receptor X2 and related products and methods ESCIENT PHARMACEUTICALS, INC. (US) 2024-03-05 US disclosed
US-20240059667-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS INCYTE CORPORATION 2024-02-22 US disclosed
WO-2023192901-A9 QUINOLINE DERIVATIVES AS MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS ESCIENT PHARMACEUTICALS, INC. (US) 2023-12-14 WO disclosed
US-11807644-B2 Methods and compounds for restoring mutant p53 function PMV PHARMACEUTICALS, INC. (US) 2023-11-07 US disclosed
US-11807644-B2 Methods and compounds for restoring mutant p53 function PMV PHARMACEUTICALS, INC. (US) 2023-11-07 US disclosed
WO-2023192901-A1 QUINOLINE DERIVATIVES AS MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS ESCIENT PHARMACEUTICALS, INC. (US) 2023-10-05 WO disclosed
EP-4217345-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS ESCIENT PHARMACEUTICALS, INC. (US) 2023-08-02 EP disclosed
CN-116406357-A Modulators of MAS-related G protein receptor X2 and related products and methods 伊赛恩特制药公司 2023-07-07 CN disclosed
US-20230065217-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS ESCIENT PHARMACEUTICALS, INC. 2023-03-02 US disclosed
WO-2022067094-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS ESCIENT PHARMACEUTICALS, INC. (US) 2022-03-31 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11919864-B2 Modulators of Mas-related G-protein receptor X2 and related products and methods MRGPRX2, MRGPRX1, MRGPRX4 AKR1B1 1468/4885CNR1 89/4885PLA2G4A 1220/4885
US-20230065217-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS MRGPRX2, MRGPRX1, MRGPRX4 AKR1B1 1468/4885CNR1 89/4885PLA2G4A 1220/4885
US-12275707-B2 Modulators of mas-related g-protein receptor X2 and related products and methods MRGPRX2, MRGPRX1, MRGPRX4 AKR1B1 1468/4885CNR1 89/4885PLA2G4A 1220/4885
US-20240124415-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS MRGPRX2, MRGPRX1, MRGPRX4 AKR1B1 1615/4885CNR1 99/4885PLA2G4A 1410/4885
US-12129244-B2 Modulators of Mas-related G-protein receptor X2 and related products and methods MRGPRX2, MRGPRX1, MRGPRX4 AKR1B1 1615/4885CNR1 99/4885PLA2G4A 1410/4885
US-11807644-B2 Methods and compounds for restoring mutant p53 function TP53, TP53BP1, HRAS AKR1B1 2961/4885CNR1 4652/4885PLA2G4A 1123/4885
US-20250026735-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS MRGPRX2, MRGPRX1, MRGPRX4 AKR1B1 1615/4885CNR1 99/4885PLA2G4A 1410/4885
US-20240124416-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS MRGPRX2, MRGPRX1, MRGPRX4 AKR1B1 1615/4885CNR1 99/4885PLA2G4A 1410/4885
US-20240336570-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS MRGPRX2, MRGPRX1, MRGPRX4 AKR1B1 1468/4885CNR1 89/4885PLA2G4A 1220/4885
US-20240124414-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS MRGPRX2, MRGPRX1, MRGPRX4 AKR1B1 1615/4885CNR1 99/4885PLA2G4A 1410/4885
US-20240059667-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS MRGPRX2, MRGPRX1, MRGPRX4 AKR1B1 1615/4885CNR1 99/4885PLA2G4A 1410/4885
US-12129243-B2 Modulators of Mas-related G-protein receptor X2 and related products and methods MRGPRX2, MRGPRX1, MRGPRX4 AKR1B1 1615/4885CNR1 99/4885PLA2G4A 1410/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.